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Bad Gene Detail
Summary
  • Symbol
    Bad
  • Name
    BCL2-associated agonist of cell death
  • Synonyms
    Bbc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096330
    NCBI Gene: 12015
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6919229-6929267 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096330
 protein coding gene Chr19:6919229-6929273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024774
 protein coding gene Chr19:4034864-4044901 (+)
A/J MGP_AJ_G0024740
 protein coding gene Chr19:3704158-3714195 (+)
AKR/J MGP_AKRJ_G0024713
 protein coding gene Chr19:3822157-3834489 (+)
BALB/cJ MGP_BALBcJ_G0024740
 protein coding gene Chr19:3812311-3823591 (+)
C3H/HeJ MGP_C3HHeJ_G0024508
 protein coding gene Chr19:3948750-3958775 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025186
 protein coding gene Chr19:4127255-4137297 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022620
 protein coding gene Chr19:3611918-3620917 (+)
CAST/EiJ MGP_CASTEiJ_G0023980
 protein coding gene Chr19:3855216-3865942 (+)
CBA/J MGP_CBAJ_G0024480
 protein coding gene Chr19:4175985-4186853 (+)
DBA/2J MGP_DBA2J_G0024607
 protein coding gene Chr19:3676523-3686598 (+)
FVB/NJ MGP_FVBNJ_G0024573
 protein coding gene Chr19:3705688-3716367 (+)
LP/J MGP_LPJ_G0024693
 protein coding gene Chr19:3894154-3905338 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024602
 protein coding gene Chr19:4081675-4094511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025234
 protein coding gene Chr19:3955348-3966330 (+)
PWK/PhJ MGP_PWKPhJ_G0023726
 protein coding gene Chr19:3720399-3730255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023531
 protein coding gene Chr19:3779707-3789489 (+)
WSB/EiJ MGP_WSBEiJ_G0024042
 protein coding gene Chr19:3858545-3870213 (+)



Homology
more
  • Human Ortholog
    BAD, BCL2 associated agonist of cell death
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAD, BCL2 associated agonist of cell death
  • Synonyms
    BBC2, BCL2L8
  • Links
    NCBI Gene ID: 572
    neXtProt AC: NX_Q92934
    UniProt: Q92934

  • Chr Location
    11q13.1; chr11:64269828-64284704 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human BAD associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are grossly normal and fertile. Both T and B cells show increased sensitivity to gamma irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    69
  • cDNA Data
    64
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024959 Ensembl Gene Model | MGI Sequence Detail 10039 C57BL/6J ±  kb
    transcript ENSMUST00000025910 Ensembl | MGI Sequence Detail 1452 Not Applicable  
    polypeptide ENSMUSP00000025910 Ensembl | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 66
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147509
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 29
      Gene Ontology 34
      Phenotypes 43
    • Earliest
      J:42326 Yang E, et al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
    • Latest
      J:341382 Wu B, et al., Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory