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Psme2 Gene Detail
Summary
  • Symbol
    Psme2
  • Name
    proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
  • Synonyms
    PA28b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096365
    NCBI Gene: 19188
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55824897-55828558 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C2-D1
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096365
 protein coding gene Chr14:55824897-55828570 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021353
 protein coding gene Chr14:49623956-49627628 (-)
A/J MGP_AJ_G0021312
 protein coding gene Chr14:48635272-48639161 (-)
AKR/J MGP_AKRJ_G0021288
 protein coding gene Chr14:50381383-50385040 (-)
BALB/cJ MGP_BALBcJ_G0021316
 protein coding gene Chr14:48581246-48584917 (-)
C3H/HeJ MGP_C3HHeJ_G0021096
 protein coding gene Chr14:50066504-50070176 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021754
 protein coding gene Chr14:52118263-52121858 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019301
 protein coding gene Chr14:47009821-47014590 (-)
CAST/EiJ MGP_CASTEiJ_G0020615
 protein coding gene Chr14:46331149-46334821 (-)
CBA/J MGP_CBAJ_G0021063
 protein coding gene Chr14:53672166-53675750 (-)
DBA/2J MGP_DBA2J_G0021184
 protein coding gene Chr14:48360250-48364130 (-)
FVB/NJ MGP_FVBNJ_G0021166
 protein coding gene Chr14:47808534-47812117 (-)
LP/J MGP_LPJ_G0021258
 protein coding gene Chr14:50667538-50671601 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021190
 protein coding gene Chr14:53035214-53038797 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021781
 protein coding gene Chr14:49568685-49572357 (-)
PWK/PhJ MGP_PWKPhJ_G0020362
 protein coding gene Chr14:44891924-44895771 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020190
 protein coding gene Chr14:45572210-45577151 (-)
WSB/EiJ MGP_WSBEiJ_G0020668
 protein coding gene Chr14:49853878-49858558 (-)



Homology
more
  • Human Ortholog
    PSME2, proteasome activator subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSME2, proteasome activator subunit 2
  • Synonyms
    PA28B, PA28beta, REGbeta
  • Links
    NCBI Gene ID: 5721
    neXtProt AC: NX_Q9UL46
    UniProt: Q9UL46

  • Chr Location
    14q12; chr14:24143362-24147570 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in impaired cytotoxic T lymphocyte responses and immunoproteasome assembly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    8
  • cDNA Data
    40
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19188 NCBI Gene Model | MGI Sequence Detail 3662 C57BL/6J ±  kb
transcript NM_011190 RefSeq | MGI Sequence Detail 906 ZRU/MplStud  
polypeptide P97372 UniProt | EBI | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    Genomic 6
    cDNA 42
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144028, MGI:2145690
References
more
  • Summaries
    All 58
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:41183 Jiang H, et al., Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Immunogenetics. 1997;46(2):93-8
  • Latest
    J:354250 Ngwaga T, et al., Effector-mediated subversion of proteasome activator (PA)28alphabeta enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions. PLoS Pathog. 2023 Jun;19(6):e1011473
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory