About   Help   FAQ
Exoc4 Gene Detail
Summary
  • Symbol
    Exoc4
  • Name
    exocyst complex component 4
  • Synonyms
    Sec8, Sec8l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096376
    NCBI Gene: 20336
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:33226025-33950914 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 14.59 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096376
 protein coding gene Chr6:33226020-33950914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030553
 protein coding gene Chr6:31262804-32018453 (+)
A/J MGP_AJ_G0030526
 protein coding gene Chr6:29941335-30664972 (+)
AKR/J MGP_AKRJ_G0030453
 protein coding gene Chr6:30940037-31683764 (+)
BALB/cJ MGP_BALBcJ_G0030536
 protein coding gene Chr6:30094437-30824330 (+)
C3H/HeJ MGP_C3HHeJ_G0030249
 protein coding gene Chr6:30917089-31659914 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030990
 protein coding gene Chr6:32060244-32836487 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028201
 protein coding gene Chr6:28052950-28755161 (+)
CAST/EiJ MGP_CASTEiJ_G0029651
 protein coding gene Chr6:30709478-31458902 (+)
CBA/J MGP_CBAJ_G0030227
 protein coding gene Chr6:33311507-34096077 (+)
DBA/2J MGP_DBA2J_G0030371
 protein coding gene Chr6:29826312-30542440 (+)
FVB/NJ MGP_FVBNJ_G0030325
 protein coding gene Chr6:29610027-30321972 (+)
LP/J MGP_LPJ_G0030458
 protein coding gene Chr6:31392121-32153551 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030361
 protein coding gene Chr6:35652714-36471309 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031020
 protein coding gene Chr6:30833402-31579709 (+)
PWK/PhJ MGP_PWKPhJ_G0029365
 protein coding gene Chr6:29414500-30140369 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029201
 protein coding gene Chr6:30485215-31218939 (+)
WSB/EiJ MGP_WSBEiJ_G0029727
 protein coding gene Chr6:30738420-31490373 (+)



Homology
more
  • Human Ortholog
    EXOC4, exocyst complex component 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOC4, exocyst complex component 4
  • Synonyms
    SEC8, SEC8L1, Sec8p
  • Links
    NCBI Gene ID: 60412
    neXtProt AC: NX_Q96A65
    UniProt: Q96A65

  • Chr Location
    7q33; chr7:133253073-134100951 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic abnormatlities. Gastrulation is not completed and mesoderm formation is abnormal. Death occurs before E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    22
  • cDNA Data
    17
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20336 NCBI Gene Model | MGI Sequence Detail 724890 C57BL/6J ±  kb
    transcript NM_009148 RefSeq | MGI Sequence Detail 4781 ZRU/MplStud  
    polypeptide O35382 UniProt | EBI | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000007251 exocyst complex component 4
      (term hierarchy)
    • InterPro Domains
      IPR039682 Exocyst complex component Sec8/EXOC4
      IPR048630 Exocyst complex component Sec8, middle helical bundle
      IPR007191 Exocyst complex component Sec8, N-terminal
    • GlyGen
      O35382 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1353571
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 10
      Gene Ontology 14
      Phenotypes 20
    • Earliest
      J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory