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Bcan Gene Detail
Summary
  • Symbol
    Bcan
  • Name
    brevican
  • Synonyms
    Cspg7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096385
    NCBI Gene: 12032
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87894838-87907537 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096385
 protein coding gene Chr3:87894838-87908458 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027378
 protein coding gene Chr3:88122490-88135207 (-)
A/J MGP_AJ_G0027342
 protein coding gene Chr3:85131729-85144422 (-)
AKR/J MGP_AKRJ_G0027308
 protein coding gene Chr3:87226363-87239099 (-)
BALB/cJ MGP_BALBcJ_G0027351
 protein coding gene Chr3:85225135-85238115 (-)
C3H/HeJ MGP_C3HHeJ_G0027094
 protein coding gene Chr3:87501817-87517920 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027797
 protein coding gene Chr3:91364002-91376704 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025150
 protein coding gene Chr3:80762754-80775790 (-)
CAST/EiJ MGP_CASTEiJ_G0026540
 protein coding gene Chr3:87710612-87723493 (-)
CBA/J MGP_CBAJ_G0027069
 protein coding gene Chr3:94458329-94476071 (-)
DBA/2J MGP_DBA2J_G0027205
 protein coding gene Chr3:84622075-84634824 (-)
FVB/NJ MGP_FVBNJ_G0027174
 protein coding gene Chr3:82895099-82908611 (-)
LP/J MGP_LPJ_G0027313
 protein coding gene Chr3:89088418-89102514 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027193
 protein coding gene Chr3:100713274-100729838 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027855
 protein coding gene Chr3:86978727-86993059 (-)
PWK/PhJ MGP_PWKPhJ_G0026273
 protein coding gene Chr3:84417574-84430954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026091
 protein coding gene Chr3:86164071-86178809 (-)
WSB/EiJ MGP_WSBEiJ_G0026620
 protein coding gene Chr3:87340170-87352851 (-)



Homology
more
  • Human Ortholog
    BCAN, brevican
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCAN, brevican
  • Synonyms
    BEHAB, CSPG7
  • Links
    NCBI Gene ID: 63827
    neXtProt AC: NX_Q96GW7
    UniProt: Q96GW7

  • Chr Location
    1q23.1; chr1:156641390-156659532 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired LTP maintenance, but mutant animals show normal behavior and spatial learning capabilities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1009
  • Tissues
    129
  • cDNA Data
    27
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004892 Ensembl Gene Model | MGI Sequence Detail 12700 C57BL/6J ±  kb
    transcript ENSMUST00000090971 Ensembl | MGI Sequence Detail 3141 Not Applicable  
    polypeptide ENSMUSP00000088491 Ensembl | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 28
      Primer pair 3
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:42589 Rauch U, et al., Sequence and chromosomal localization of the mouse brevican gene. Genomics. 1997 Aug 15;44(1):15-21
    • Latest
      J:351222 Reinhard J, et al., Neural extracellular matrix regulates visual sensory motor integration. iScience. 2024 Feb 16;27(2):108846
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory