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Ankrd1 Gene Detail
Summary
  • Symbol
    Ankrd1
  • Name
    ankyrin repeat domain 1
  • Synonyms
    Alrp, CARP, Crap, MARP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097717
    NCBI Gene: 107765
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:36089365-36097244 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 30.52 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097717
 protein coding gene Chr19:36089361-36097499 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025070
 protein coding gene Chr19:34960452-34968895 (-)
A/J MGP_AJ_G0025046
 protein coding gene Chr19:33294481-33302399 (-)
AKR/J MGP_AKRJ_G0025014
 protein coding gene Chr19:34411565-34419480 (-)
BALB/cJ MGP_BALBcJ_G0025044
 protein coding gene Chr19:33383179-33390949 (-)
C3H/HeJ MGP_C3HHeJ_G0024803
 protein coding gene Chr19:34479453-34488303 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025485
 protein coding gene Chr19:35979700-35989179 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022903
 protein coding gene Chr19:32671645-32680391 (-)
CAST/EiJ MGP_CASTEiJ_G0024270
 protein coding gene Chr19:34263283-34271037 (-)
CBA/J MGP_CBAJ_G0024780
 protein coding gene Chr19:37687453-37696904 (-)
DBA/2J MGP_DBA2J_G0024912
 protein coding gene Chr19:33161907-33169415 (-)
FVB/NJ MGP_FVBNJ_G0024873
 protein coding gene Chr19:32968927-32976752 (-)
LP/J MGP_LPJ_G0024998
 protein coding gene Chr19:35054893-35064939 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024904
 protein coding gene Chr19:37519201-37527449 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025543
 protein coding gene Chr19:34500226-34507974 (-)
PWK/PhJ MGP_PWKPhJ_G0024022
 protein coding gene Chr19:32973370-32981424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023822
 protein coding gene Chr19:33337156-33345660 (-)
WSB/EiJ MGP_WSBEiJ_G0024337
 protein coding gene Chr19:34591613-34600586 (-)



Homology
more
  • Human Ortholog
    ANKRD1, ankyrin repeat domain 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKRD1, ankyrin repeat domain 1
  • Synonyms
    ALRP, bA320F15.2, C-193, CARP, CVARP, MCARP
  • Links
    NCBI Gene ID: 27063
    neXtProt AC: NX_Q15327
    UniProt: Q15327

  • Chr Location
    10q23.31; chr10:90912096-90921087 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human ANKRD1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile, and show no apparent cardiac phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    83
  • cDNA Data
    52
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107765 NCBI Gene Model | MGI Sequence Detail 7880 C57BL/6J ±  kb
    transcript NM_013468 RefSeq | MGI Sequence Detail 1765 C57BL/6  
    polypeptide Q9CR42 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 2
      cDNA 53
      Primer pair 2
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39620, MGI:109621
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 37
      Gene Ontology 14
      Phenotypes 15
    • Earliest
      J:38213 Arber S, et al., MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 1997 Feb 7;88(3):393-403
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory