Kif14 MGI Mouse Gene Detail - MGI:1098226

Symbol

Kif14
Name

kinesin family member 14
Synonyms

D1Ertd367e, N-3 kinesin

Feature Type

protein coding gene
IDs

MGI:1098226
NCBI Gene: 381293
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:136394081-136459249 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.80 cM, cytoband F
Mapping Data

4 experiments

SNPs within 2kb

2474 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098226	protein coding gene	Chr1:136394044-136483676 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016542	protein coding gene	Chr1:140298669-140369748 (+)
A/J	MGP_AJ_G0016525	protein coding gene	Chr1:134974699-135041220 (+)
AKR/J	MGP_AKRJ_G0016490	protein coding gene	Chr1:138984715-139052936 (+)
BALB/cJ	MGP_BALBcJ_G0016485	protein coding gene	Chr1:135305617-135370509 (+)
C3H/HeJ	MGP_C3HHeJ_G0016311	protein coding gene	Chr1:139090654-139158802 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016946	protein coding gene	Chr1:145309006-145377534 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014657	protein coding gene	Chr1:128089601-128156282 (+)
CAST/EiJ	MGP_CASTEiJ_G0015891	protein coding gene	Chr1:138198316-138268859 (+)
CBA/J	MGP_CBAJ_G0016284	protein coding gene	Chr1:150348070-150417694 (+)
DBA/2J	MGP_DBA2J_G0016390	protein coding gene	Chr1:133968830-134038248 (+)
FVB/NJ	MGP_FVBNJ_G0016389	protein coding gene	Chr1:132617410-132683515 (+)
LP/J	MGP_LPJ_G0016461	protein coding gene	Chr1:141511640-141579799 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016414	protein coding gene	Chr1:155978252-156056342 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016982	protein coding gene	Chr1:138752779-138821526 (+)
PWK/PhJ	MGP_PWKPhJ_G0015677	protein coding gene	Chr1:133020098-133088623 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015464	protein coding gene	Chr1:137743726-137815789 (+)
WSB/EiJ	MGP_WSBEiJ_G0015954	protein coding gene	Chr1:138794425-138865624 (+)

Human Ortholog

KIF14, kinesin family member 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF14, kinesin family member 14
Synonyms

MCPH20, MKS12
Links

HGNC:19181

NCBI Gene ID: 9928

neXtProt AC: NX_Q15058

UniProt: Q15058
Chr Location

1q32.1; chr1:200551497-200620751 (-) GRCh38

MGI Vertebrate Homology

Kif14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF14
Gene Tree

Kif14

Diseases

2 with human KIF14 associations

				Human Disease	Mouse Models
				Meckel syndrome IDs Meckel syndrome DOID:0050778 ICD9CM:753.1 ICD9CM:753.10 OMIM:PS249000 ORDO:564 UMLS_CUI:C0311245
				primary autosomal recessive microcephaly IDs primary autosomal recessive microcephaly DOID:0070296 OMIM:PS251200 ORDO:2512

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

34 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

12
Radiation induced

1
Spontaneous

1
Targeted

1
Transgenic

1
Genomic Mutations

3 involving Kif14
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a spontaneous mutation or targeted allele exhibit severe brain malformations, neurological defects and hypomyelination.

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All GO Annotations

68
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

7
cDNA Data

19
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIF14

Xenbase kif14, kif14l

ZFIN kif14

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All Sequences

66
RefSeq

16
UniProt

9
CCDS

CCDS78693.1

Ensembl

ENSMUSG00000041498 (Evidence)
NCBI Gene

381293

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041498	Ensembl Gene Model \| MGI Sequence Detail	65169	C57BL/6J	± kb
transcript	ENSMUST00000189413	Ensembl \| MGI Sequence Detail	8943	Not Applicable
polypeptide	ENSMUSP00000139698	Ensembl \| MGI Sequence Detail	1674	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000009288 kinesin-like protein KIF14

(term hierarchy)
PDB

4OZQ, 6WWE, 6WWF, 6WWG, 6WWH, 6WWI, 6WWJ, 6WWK, 6WWL, 6WWM, 6WWN, 6WWO, 6WWP, 6WWQ, 6WWR, 6WWS, 6WWT, 6WWU, 6WWV, 7LVQ, 7LVR
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR032405 Kinesin-associated

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR008984 SMAD/FHA domain superfamily

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All nucleic 23

Genomic 1

cDNA 19

Primer pair 3

Microarray probesets 3

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MGI:1196255

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:269628 Sishtla K, et al., Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14. Sci Rep. 2018 Nov 1;8(1):16152

TSS for Kif14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9064	Chr1:136394074-136394116 (+)	14 bp
Tssr9065	Chr1:136394121-136394143 (+)	51 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24