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Nrg2 Gene Detail
Summary
  • Symbol
    Nrg2
  • Name
    neuregulin 2
  • Synonyms
    Don1, NTAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098246
    NCBI Gene: 100042150
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36150705-36330433 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3761 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098246
 protein coding gene Chr18:36147634-36332754 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024274
 protein coding gene Chr18:34381927-34575508 (-)
A/J MGP_AJ_G0024240
 protein coding gene Chr18:33182428-33367590 (-)
AKR/J MGP_AKRJ_G0024208
 protein coding gene Chr18:34107055-34289398 (-)
BALB/cJ MGP_BALBcJ_G0024240
 protein coding gene Chr18:33230356-33414560 (-)
C3H/HeJ MGP_C3HHeJ_G0024007
 protein coding gene Chr18:34164042-34354038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024681
 protein coding gene Chr18:35608236-35798444 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022121
 protein coding gene Chr18:33281100-33462131 (-)
CAST/EiJ MGP_CASTEiJ_G0023482
 protein coding gene Chr18:34151520-34350457 (-)
CBA/J MGP_CBAJ_G0023975
 protein coding gene Chr18:36638900-36845569 (-)
DBA/2J MGP_DBA2J_G0024107
 protein coding gene Chr18:32812739-32995676 (-)
FVB/NJ MGP_FVBNJ_G0024074
 protein coding gene Chr18:32511958-32693878 (-)
LP/J MGP_LPJ_G0024189
 protein coding gene Chr18:34414580-34608200 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024102
 protein coding gene Chr18:37865539-38058022 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024730
 protein coding gene Chr18:33969482-34158889 (-)
PWK/PhJ MGP_PWKPhJ_G0023226
 protein coding gene Chr18:33045869-33231661 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023033
 protein coding gene Chr18:34227899-34420202 (-)
WSB/EiJ MGP_WSBEiJ_G0023545
 protein coding gene Chr18:33888528-34083024 (-)



Homology
more
  • Human Ortholog
    NRG2, neuregulin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRG2, neuregulin 2
  • Synonyms
    DON1, HRG2, NTAK
  • Links
    NCBI Gene ID: 9542
    neXtProt AC: NX_O14511
    UniProt: O14511

  • Chr Location
    5q31.2; chr5:139846779-140043299 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About one third of mice homozygous for a knock-out allele die prior to weaning in the absence of cardiac defects or other morphological abnormalities. Homozygotes display an early but transient postnatal growth deficit and reduced reproductive capacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    39
  • cDNA Data
    21
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060275 Ensembl Gene Model | MGI Sequence Detail 179729 C57BL/6J ±  kb
    transcript ENSMUST00000115713 Ensembl | MGI Sequence Detail 3056 Not Applicable  
    polypeptide ENSMUSP00000111378 Ensembl | MGI Sequence Detail 857 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 21
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:894700
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:41106 Busfield SJ, et al., Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. Mol Cell Biol. 1997 Jul;17(7):4007-14
    • Latest
      J:334091 Zhang X, et al., Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. iScience. 2023 Mar 17;26(3):106242
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory