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Astn1 Gene Detail
Summary
  • Symbol
    Astn1
  • Name
    astrotactin 1
  • Synonyms
    mKIAA0289
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098567
    NCBI Gene: 11899
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:158189843-158519351 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 68.35 cM, cytoband H1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8640 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098567
 protein coding gene Chr1:158189647-158519351 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016635
 protein coding gene Chr1:163461895-163797516 (+)
A/J MGP_AJ_G0016616
 protein coding gene Chr1:156829496-157158327 (+)
AKR/J MGP_AKRJ_G0016582
 protein coding gene Chr1:161630472-161961407 (+)
BALB/cJ MGP_BALBcJ_G0016577
 protein coding gene Chr1:157357784-157682270 (+)
C3H/HeJ MGP_C3HHeJ_G0016401
 protein coding gene Chr1:161784973-162114701 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017038
 protein coding gene Chr1:169034267-169393183 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014747
 protein coding gene Chr1:149005206-149324296 (+)
CAST/EiJ MGP_CASTEiJ_G0015981
 protein coding gene Chr1:161341686-161689947 (+)
CBA/J MGP_CBAJ_G0016376
 protein coding gene Chr1:175027600-175369655 (+)
DBA/2J MGP_DBA2J_G0016482
 protein coding gene Chr1:155784600-156110368 (+)
FVB/NJ MGP_FVBNJ_G0016480
 protein coding gene Chr1:154232194-154557423 (+)
LP/J MGP_LPJ_G0016553
 protein coding gene Chr1:164552077-164895420 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016505
 protein coding gene Chr1:182580971-182922303 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017074
 protein coding gene Chr1:161463563-161805522 (+)
PWK/PhJ MGP_PWKPhJ_G0015767
 protein coding gene Chr1:154899919-155235294 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015554
 protein coding gene Chr1:160250057-160581468 (+)
WSB/EiJ MGP_WSBEiJ_G0016043
 protein coding gene Chr1:161587178-161915657 (+)



Homology
more
  • Human Ortholog
    ASTN1, astrotactin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASTN1, astrotactin 1
  • Synonyms
    ASTN
  • Links
    NCBI Gene ID: 460
    neXtProt AC: NX_O14525
    UniProt: O14525

  • Chr Location
    1q25.2; chr1:176857302-177164973 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced cerebellum size, abnormal Purkinje cell morphology, and reduced coordination performance on the Rotarod test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    40
  • cDNA Data
    97
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026587 Ensembl Gene Model | MGI Sequence Detail 329509 C57BL/6J ±  kb
    transcript ENSMUST00000193042 Ensembl | MGI Sequence Detail 7248 Not Applicable  
    polypeptide ENSMUSP00000142322 Ensembl | MGI Sequence Detail 1302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:192652 Fishell G, et al., Astrotactin provides a receptor system for CNS neuronal migration. Development. 1991 Nov;113(3):755-65
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory