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Wasf2 Gene Detail
Summary
  • Symbol
    Wasf2
  • Name
    WASP family, member 2
  • Synonyms
    D4Ertd13e, WAVE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098641
    NCBI Gene: 242687
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132857843-132927067 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1903 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098641
 protein coding gene Chr4:132857816-132927067 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028886
 protein coding gene Chr4:135355621-135431604 (+)
A/J MGP_AJ_G0028845
 protein coding gene Chr4:129699219-129769076 (+)
AKR/J MGP_AKRJ_G0028798
 protein coding gene Chr4:133374581-133449082 (+)
BALB/cJ MGP_BALBcJ_G0028868
 protein coding gene Chr4:130318991-130388970 (+)
C3H/HeJ MGP_C3HHeJ_G0028582
 protein coding gene Chr4:133626597-133698576 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029310
 protein coding gene Chr4:140228490-140305175 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026581
 protein coding gene Chr4:122779239-122846308 (+)
CAST/EiJ MGP_CASTEiJ_G0028015
 protein coding gene Chr4:131725141-131810485 (+)
CBA/J MGP_CBAJ_G0028548
 protein coding gene Chr4:143871658-143959575 (+)
DBA/2J MGP_DBA2J_G0028697
 protein coding gene Chr4:130119198-130188375 (+)
FVB/NJ MGP_FVBNJ_G0028664
 protein coding gene Chr4:128990149-129061543 (+)
LP/J MGP_LPJ_G0028798
 protein coding gene Chr4:135489030-135561107 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028690
 protein coding gene Chr4:148407481-148484838 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029348
 protein coding gene Chr4:133794259-133870654 (+)
PWK/PhJ MGP_PWKPhJ_G0027736
 protein coding gene Chr4:126823557-126894514 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027562
 protein coding gene Chr4:129637015-129710526 (+)
WSB/EiJ MGP_WSBEiJ_G0028095
 protein coding gene Chr4:133962169-134036375 (+)



Homology
more
  • Human Ortholog
    WASF2, WASP family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASF2, WASP family member 2
  • Synonyms
    dJ393P12.2, IMD2, SCAR2, WASF4, WAVE2
  • Links
    NCBI Gene ID: 10163
    neXtProt AC: NX_Q9Y6W5
    UniProt: Q9Y6W5

  • Chr Location
    1p36.11; chr1:27404230-27490167 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 5 alleles in 5 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    25
  • cDNA Data
    157
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242687 NCBI Gene Model | MGI Sequence Detail 69225 C57BL/6J ±  kb
    transcript NM_001419443 RefSeq | MGI Sequence Detail 5728 ZRU/MplStud  
    polypeptide Q8BH43 UniProt | EBI | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 159
      cDNA 157
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2140610
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 10
      Gene Ontology 18
      Phenotypes 22
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory