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Lbp Gene Detail
Summary
  • Symbol
    Lbp
  • Name
    lipopolysaccharide binding protein
  • Synonyms
    Bpifd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098776
    NCBI Gene: 16803
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:158148413-158174772 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1019 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098776
 protein coding gene Chr2:158148413-158174772 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026792
 protein coding gene Chr2:163374167-163403445 (+)
A/J MGP_AJ_G0026758
 protein coding gene Chr2:156821422-156847735 (+)
AKR/J MGP_AKRJ_G0026729
 protein coding gene Chr2:161445660-161472237 (+)
BALB/cJ MGP_BALBcJ_G0026767
 protein coding gene Chr2:157125810-157152343 (+)
C3H/HeJ MGP_C3HHeJ_G0026509
 protein coding gene Chr2:161770120-161799061 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027216
 protein coding gene Chr2:168242603-168272934 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024586
 protein coding gene Chr2:150260009-150285759 (+)
CAST/EiJ MGP_CASTEiJ_G0025971
 protein coding gene Chr2:162126598-162159348 (+)
CBA/J MGP_CBAJ_G0026486
 protein coding gene Chr2:174274596-174303713 (+)
DBA/2J MGP_DBA2J_G0026624
 protein coding gene Chr2:155995336-156021977 (+)
FVB/NJ MGP_FVBNJ_G0026591
 protein coding gene Chr2:154404284-154431265 (+)
LP/J MGP_LPJ_G0026727
 protein coding gene Chr2:163463084-163494771 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026612
 protein coding gene Chr2:178071373-178099034 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027272
 protein coding gene Chr2:161273165-161299694 (+)
PWK/PhJ MGP_PWKPhJ_G0025705
 protein coding gene Chr2:155522054-155549670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025508
 protein coding gene Chr2:160180714-160213183 (+)
WSB/EiJ MGP_WSBEiJ_G0026041
 protein coding gene Chr2:162161114-162187432 (+)



Homology
more
  • Human Ortholog
    LBP, lipopolysaccharide binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LBP, lipopolysaccharide binding protein
  • Synonyms
    BPIFD2
  • Links
    NCBI Gene ID: 3929
    neXtProt AC: NX_P18428
    UniProt: P18428

  • Chr Location
    20q11.23; chr20:38346482-38377013 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice have a generally normal phenotype but have an increased sensitivity to infection by gram negative bacteria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    8
  • cDNA Data
    170
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16803 NCBI Gene Model | MGI Sequence Detail 26360 C57BL/6J ±  kb
    transcript NM_008489 RefSeq | MGI Sequence Detail 2528 ZRU/MplStud  
    polypeptide Q61805 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001773 lipopolysaccharide-binding protein
      (term hierarchy)
    • PDB
      4M4D
    • InterPro Domains
      IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily
      IPR032942 BPI/LBP/Plunc family
      IPR030675 Lipid binding protein BPI/LBP
      IPR017954 Lipid-binding serum glycoprotein, conserved site
      IPR001124 Lipid-binding serum glycoprotein, C-terminal
      IPR017942 Lipid-binding serum glycoprotein, N-terminal
    • GlyGen
      Q61805 3 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 174
      Genomic 3
      cDNA 170
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 30
    • Earliest
      J:45749 Lengacher S, et al., Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria. J Inflamm. 1995-96;47(4):165-72
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory