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Nrp2 Gene Detail
Summary
  • Symbol
    Nrp2
  • Name
    neuropilin 2
  • Synonyms
    1110048P06Rik, NP-2, NP2, Npn-2, Npn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100492
    NCBI Gene: 18187
  • Alliance
  • Transcription Start Sites
    63 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:62742476-62857851 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 31.35 cM, cytoband C2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2392 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100492
protein coding gene Chr1:62742444-62857854 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016083
protein coding gene Chr1:62822120-62945321 (+)
A/J MGP_AJ_G0016066
protein coding gene Chr1:60601175-60717953 (+)
AKR/J MGP_AKRJ_G0016023
protein coding gene Chr1:62278197-62396128 (+)
BALB/cJ MGP_BALBcJ_G0016021
protein coding gene Chr1:60672066-60792578 (+)
C3H/HeJ MGP_C3HHeJ_G0015853
protein coding gene Chr1:62539847-62660116 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016474
protein coding gene Chr1:65236528-65366416 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014195
protein coding gene Chr1:56731784-56847198 (+)
CAST/EiJ MGP_CASTEiJ_G0015436
protein coding gene Chr1:61789082-61913504 (+)
CBA/J MGP_CBAJ_G0015825
protein coding gene Chr1:67321864-67448519 (+)
DBA/2J MGP_DBA2J_G0015926
protein coding gene Chr1:60012170-60128818 (+)
FVB/NJ MGP_FVBNJ_G0015929
protein coding gene Chr1:59313604-59430548 (+)
LP/J MGP_LPJ_G0015998
protein coding gene Chr1:63709574-63830727 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015949
protein coding gene Chr1:70242905-70365650 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016521
protein coding gene Chr1:62245087-62363619 (+)
PWK/PhJ MGP_PWKPhJ_G0015223
protein coding gene Chr1:59384783-59501168 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015002
protein coding gene Chr1:61748826-61867477 (+)
WSB/EiJ MGP_WSBEiJ_G0015498
protein coding gene Chr1:61970031-62098949 (+)



Homology
more
  • Human Ortholog
    NRP2, neuropilin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRP2, neuropilin 2
  • Synonyms
    NP2, NPN2, PRO2714, VEGF165R2
  • Links
    NCBI Gene ID: 8828
    neXtProt AC: NX_O60462
    UniProt: O60462

  • Chr Location
    2q33.3; chr2:205681990-205798133 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Nrp2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 5 alleles in 9 genetic backgrounds
    16 phenotypes from multigenic genotypes
    4 images
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18187 NCBI Gene Model | MGI Sequence Detail 115376 C57BL/6J ±  kb
    transcript NM_001077403 RefSeq | MGI Sequence Detail 6739 C57BL/6  
    polypeptide O35375 UniProt | EBI | MGI Sequence Detail 931 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 88
      Primer pair 8
      Other 19

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916002
    References
    more
    • Summaries
      All 345
      Developmental Gene Expression 244
      Diseases 1
      Gene Ontology 19
      Phenotypes 101
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354188 Vallecillo-Garcia P, et al., Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation. Development. 2024 Sep 1;151(17):dev202747

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/12/2024
    MGI 6.24
    The Jackson Laboratory