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Flot1 Gene Detail
Summary
  • Symbol
    Flot1
  • Name
    flotillin 1
  • Synonyms
    reggie-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100500
    NCBI Gene: 14251
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36134243-36143674 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100500
 protein coding gene Chr17:36134122-36143683 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023653
 protein coding gene Chr17:36017886-36027450 (+)
A/J MGP_AJ_G0023608
 protein coding gene Chr17:34902807-34912639 (+)
AKR/J MGP_AKRJ_G0023578
 protein coding gene Chr17:35329007-35338590 (+)
BALB/cJ MGP_BALBcJ_G0023613
 protein coding gene Chr17:35047100-35056724 (+)
C3H/HeJ MGP_C3HHeJ_G0023379
 protein coding gene Chr17:35794337-35803921 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024055
 protein coding gene Chr17:37489297-37498848 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021533
 protein coding gene Chr17:32598731-32608609 (+)
CAST/EiJ MGP_CASTEiJ_G0022870
 protein coding gene Chr17:35905389-35914945 (+)
CBA/J MGP_CBAJ_G0023357
 protein coding gene Chr17:39068245-39080332 (+)
DBA/2J MGP_DBA2J_G0023481
 protein coding gene Chr17:34209236-34219043 (+)
FVB/NJ MGP_FVBNJ_G0023452
 protein coding gene Chr17:34005736-34015291 (+)
LP/J MGP_LPJ_G0023561
 protein coding gene Chr17:36398369-36407988 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023473
 protein coding gene Chr17:37832946-37848548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024098
 protein coding gene Chr17:35644103-35653609 (+)
PWK/PhJ MGP_PWKPhJ_G0022621
 protein coding gene Chr17:33070502-33080376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022440
 protein coding gene Chr17:33691230-33704957 (+)
WSB/EiJ MGP_WSBEiJ_G0022936
 protein coding gene Chr17:35792150-35801746 (+)



Homology
more
  • Human Ortholog
    FLOT1, flotillin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLOT1, flotillin 1
  • Links
    NCBI Gene ID: 10211
    neXtProt AC: NX_O75955
    UniProt: O75955

  • Chr Location
    6p21.33; chr6:30727709-30742732 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired neutrophil recruitment. Homozygous double KO with Flot2 increases susceptibility to induced necroptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    116
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    109
  • cDNA Data
    95
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14251 NCBI Gene Model | MGI Sequence Detail 9432 C57BL/6J ±  kb
transcript NM_001410127 RefSeq | MGI Sequence Detail 1699 C57BL/6  
polypeptide O08917 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 95
    Primer pair 1
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 62
    Developmental Gene Expression 6
    Gene Ontology 18
    Phenotypes 11
  • Earliest
    J:40485 Bickel PE, et al., Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997 May 23;272(21):13793-802
  • Latest
    J:342152 Honda A, et al., Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts. Cell Rep. 2023 Oct 31;42(10):113195
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory