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Nr2e1 Gene Detail
Summary
  • Symbol
    Nr2e1
  • Name
    nuclear receptor subfamily 2, group E, member 1
  • Synonyms
    Mtll, Nr2e1, tailless, Tlx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100526
    NCBI Gene: 21907
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:42437959-42459628 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    445 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100526
 protein coding gene Chr10:42437959-42459721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017186
 protein coding gene Chr10:41285370-41307069 (-)
A/J MGP_AJ_G0017163
 protein coding gene Chr10:40121329-40141125 (-)
AKR/J MGP_AKRJ_G0017123
 protein coding gene Chr10:40730202-40751641 (-)
BALB/cJ MGP_BALBcJ_G0017125
 protein coding gene Chr10:40182481-40203166 (-)
C3H/HeJ MGP_C3HHeJ_G0016946
 protein coding gene Chr10:41073932-41095866 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017584
 protein coding gene Chr10:42531362-42554071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015280
 protein coding gene Chr10:37977332-37996726 (-)
CAST/EiJ MGP_CASTEiJ_G0016525
 protein coding gene Chr10:41265663-41288677 (-)
CBA/J MGP_CBAJ_G0016920
 protein coding gene Chr10:44491055-44524780 (-)
DBA/2J MGP_DBA2J_G0017025
 protein coding gene Chr10:39602789-39622627 (-)
FVB/NJ MGP_FVBNJ_G0017020
 protein coding gene Chr10:39098175-39117822 (-)
LP/J MGP_LPJ_G0017102
 protein coding gene Chr10:41276117-41295975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017050
 protein coding gene Chr10:45233263-45254486 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017621
 protein coding gene Chr10:40711696-40731298 (-)
PWK/PhJ MGP_PWKPhJ_G0016305
 protein coding gene Chr10:39474716-39496565 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016089
 protein coding gene Chr10:40536654-40556259 (-)
WSB/EiJ MGP_WSBEiJ_G0016588
 protein coding gene Chr10:41013055-41033678 (-)



Homology
more
  • Human Ortholog
    NR2E1, nuclear receptor subfamily 2 group E member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR2E1, nuclear receptor subfamily 2 group E member 1
  • Synonyms
    TLL, TLX, XTLL
  • Links
    NCBI Gene ID: 7101
    neXtProt AC: NX_Q9Y466
    UniProt: Q9Y466

  • Chr Location
    6q21; chr6:108166022-108188809 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 5 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes have small brains, hypoplasia of cerebrum and olfactory lobes, thin optic layers, reduced retinal vessels and hydrocephaly on some genetic backgrounds. Mutants do poorly in sensorimotor tests, are aggressive and females lack maternal behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1099
  • Tissues
    200
  • cDNA Data
    31
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019803 Ensembl Gene Model | MGI Sequence Detail 21670 C57BL/6J ±  kb
    transcript ENSMUST00000019938 Ensembl | MGI Sequence Detail 3285 Not Applicable  
    polypeptide ENSMUSP00000019938 Ensembl | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011402 nuclear receptor subfamily 2 group E member 1
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR033544 Nuclear receptor subfamily 0 group B member 1/2
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 32
      Primer pair 6
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1891035
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 34
      Gene Ontology 26
      Phenotypes 54
    • Earliest
      J:13044 Carter TC, The genetics of luxate mice. III. Horseshoe kidney, hydronephrosis and lumbar reduction. J Genet. 1953;51(3):443-457
    • Latest
      J:339542 Duan LJ, et al., Tailless and hypoxia inducible factor-2alpha cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice. Biol Open. 2023 Jan 1;12(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory