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Gcnt2 Gene Detail
Summary
  • Symbol
    Gcnt2
  • Name
    glucosaminyl (N-acetyl) transferase 2 (I blood group)
  • Synonyms
    5330430K10Rik, IGnT, IGnTA, IGnTB, IGnTC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100870
    NCBI Gene: 14538
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:41013417-41114368 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 20.12 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100870
 protein coding gene Chr13:41013230-41114368 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020480
 protein coding gene Chr13:39326660-39434431 (+)
A/J MGP_AJ_G0020434
 protein coding gene Chr13:38020495-38120066 (+)
AKR/J MGP_AKRJ_G0020412
 protein coding gene Chr13:39051358-39157936 (+)
BALB/cJ MGP_BALBcJ_G0020430
 protein coding gene Chr13:38204820-38308909 (+)
C3H/HeJ MGP_C3HHeJ_G0020229
 protein coding gene Chr13:38931600-39038407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020863
 protein coding gene Chr13:40577737-40684021 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018450
 protein coding gene Chr13:36157645-36259705 (+)
CAST/EiJ MGP_CASTEiJ_G0019744
 protein coding gene Chr13:38698436-38814281 (+)
CBA/J MGP_CBAJ_G0020190
 protein coding gene Chr13:42307362-42429424 (+)
DBA/2J MGP_DBA2J_G0020312
 protein coding gene Chr13:37595010-37697162 (+)
FVB/NJ MGP_FVBNJ_G0020291
 protein coding gene Chr13:37082844-37188003 (+)
LP/J MGP_LPJ_G0020387
 protein coding gene Chr13:39568702-39671226 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020320
 protein coding gene Chr13:42293227-42410245 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020906
 protein coding gene Chr13:38694124-38804311 (+)
PWK/PhJ MGP_PWKPhJ_G0019499
 protein coding gene Chr13:37665491-37758811 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019329
 protein coding gene Chr13:37310433-37420786 (+)
WSB/EiJ MGP_WSBEiJ_G0019806
 protein coding gene Chr13:39004728-39110333 (+)



Homology
more
  • Human Ortholog
    GCNT2, glucosaminyl (N-acetyl) transferase 2 (I blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCNT2, glucosaminyl (N-acetyl) transferase 2 (I blood group)
  • Synonyms
    bA360O19.2, bA421M1.1, CCAT, CTRCT13, GCNT2C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3
  • Links
    NCBI Gene ID: 2651
    neXtProt AC: NX_Q8N0V5
    UniProt: Q8N0V5

  • Chr Location
    6p24.3-p24.2; chr6:10492223-10629368 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GCNT2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show hypoactivity, a reduced B cell number, epidermoid cyst formation in male abdominal skin, and impaired renal function with increased blood urea nitrogen and creatinine levels and vacuolization of renal tubular epithelial cells in aging mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    113
  • cDNA Data
    19
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14538 NCBI Gene Model | MGI Sequence Detail 100952 C57BL/6J ±  kb
    transcript NM_023887 RefSeq | MGI Sequence Detail 4170 ZRU/MplStud  
    polypeptide P97402 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1925531
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:310858 Henion TR, et al., N-linked polylactosamine glycan synthesis is regulated by co-expression of beta3GnT2 and GCNT2. J Cell Physiol. 2014 Apr;229(4):471-8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory