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Fxyd2 Gene Detail
Summary
  • Symbol
    Fxyd2
  • Name
    FXYD domain-containing ion transport regulator 2
  • Synonyms
    Atp1g1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195260
    NCBI Gene: 11936
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45311007-45321576 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    420 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195260
 protein coding gene Chr9:45310967-45321576 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034738
 protein coding gene Chr9:43962219-43969445 (+)
A/J MGP_AJ_G0034719
 protein coding gene Chr9:42737030-42744199 (+)
AKR/J MGP_AKRJ_G0034646
 protein coding gene Chr9:43611845-43619132 (+)
BALB/cJ MGP_BALBcJ_G0034710
 protein coding gene Chr9:42464394-42471538 (+)
C3H/HeJ MGP_C3HHeJ_G0034421
 protein coding gene Chr9:44069152-44076292 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035231
 protein coding gene Chr9:45250375-45257522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032145
 protein coding gene Chr9:42281967-42289108 (+)
CAST/EiJ MGP_CASTEiJ_G0033743
 protein coding gene Chr9:43929865-43937077 (+)
CBA/J MGP_CBAJ_G0034393
 protein coding gene Chr9:46909499-46916646 (+)
DBA/2J MGP_DBA2J_G0034552
 protein coding gene Chr9:42618914-42626058 (+)
FVB/NJ MGP_FVBNJ_G0034493
 protein coding gene Chr9:41880942-41888578 (+)
LP/J MGP_LPJ_G0034633
 protein coding gene Chr9:44268517-44275747 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034537
 protein coding gene Chr9:48708543-48715687 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035252
 protein coding gene Chr9:43534898-43542040 (+)
PWK/PhJ MGP_PWKPhJ_G0033448
 protein coding gene Chr9:42509220-42516435 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033284
 protein coding gene Chr9:43836162-43840329 (+)
WSB/EiJ MGP_WSBEiJ_G0033856
 protein coding gene Chr9:43564850-43572037 (+)



Homology
more
  • Human Ortholog
    FXYD2, FXYD domain containing ion transport regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FXYD2, FXYD domain containing ion transport regulator 2
  • Synonyms
    ATP1G1, HOMG2
  • Links
    NCBI Gene ID: 486
    neXtProt AC: NX_P54710
    UniProt: P54710

  • Chr Location
    11q23.3; chr11:117800844-117828698 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FXYD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Homozygous null mice are viable and fertile but display abnormal renal NaK-ATPase kinetics.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    82
  • cDNA Data
    194
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11936 NCBI Gene Model | MGI Sequence Detail 10570 C57BL/6J ±  kb
transcript NM_001404664 RefSeq | MGI Sequence Detail 1076 C57BL/6  
polypeptide Q04646 UniProt | EBI | MGI Sequence Detail 70 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007714 sodium/potassium-transporting ATPase subunit gamma
    (term hierarchy)
  • InterPro Domains
    IPR000272 Ion-transport regulator, FXYD family
    IPR047297 Ion-transport regulator, FXYD motif
    IPR047282 Sodium/potassium-transporting ATPase subunit gamma
Molecular
Reagents
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  • All nucleic 199
    cDNA 195
    Primer pair 4

    Microarray probesets 5
References
more
  • Summaries
    All 45
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:39176 Mercer RW, et al., Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase. J Cell Biol. 1993 May;121(3):579-86
  • Latest
    J:336270 Chernova I, et al., The ion transporter Na(+)-K(+)-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Sci Adv. 2023 Feb 3;9(5):eadf8156
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory