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Rdh1 Gene Detail
Summary
  • Symbol
    Rdh1
  • Name
    retinol dehydrogenase 1 (all trans)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195275
    NCBI Gene: 107605
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127595595-127604168 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 75.21 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    310 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195275
 protein coding gene Chr10:127595590-127604168 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017835
 protein coding gene Chr10:131391491-131403468 (+)
A/J MGP_AJ_G0017810
 protein coding gene Chr10:126132933-126143780 (+)
AKR/J MGP_AKRJ_G0017773
 protein coding gene Chr10:129851649-129865460 (+)
BALB/cJ MGP_BALBcJ_G0017774
 protein coding gene Chr10:126533327-126542104 (+)
C3H/HeJ MGP_C3HHeJ_G0017598
 protein coding gene Chr10:130010088-130018121 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018229
 protein coding gene Chr10:135838529-135848963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015909
 protein coding gene Chr10:120114091-120119657 (+)
CAST/EiJ MGP_CASTEiJ_G0017158
 protein coding gene Chr10:130679039-130689665 (+)
CBA/J MGP_CBAJ_G0017567
 protein coding gene Chr10:141327378-141335950 (+)
DBA/2J MGP_DBA2J_G0017673
 protein coding gene Chr10:125207119-125215618 (+)
FVB/NJ MGP_FVBNJ_G0017668
 protein coding gene Chr10:124152095-124162087 (+)
LP/J MGP_LPJ_G0017747
 protein coding gene Chr10:131966223-131976510 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017696
 protein coding gene Chr10:143997314-144006182 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018269
 protein coding gene Chr10:129932502-129941902 (+)
PWK/PhJ MGP_PWKPhJ_G0016943
 protein coding gene Chr10:125414989-125423736 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016735
 protein coding gene Chr10:128954933-128964382 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RDH16, retinol dehydrogenase 16
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RDH16, retinol dehydrogenase 16
  • Synonyms
    hRDH-E, RODH-4, RODH4, SDR9C8
  • Links
    NCBI Gene ID: 8608
    neXtProt AC: NX_O75452
    UniProt: O75452

  • Chr Location
    12q13.3; chr12:56951431-56959374 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased body weight, adipose tissue, and retinol levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    29
  • cDNA Data
    7
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107605 NCBI Gene Model | MGI Sequence Detail 8574 C57BL/6J ±  kb
    transcript NM_080436 RefSeq | MGI Sequence Detail 3890 ZRU/MplStud  
    polypeptide NP_536684 RefSeq | MGI Sequence Detail 317 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036291 NAD(P)-binding domain superfamily
      IPR020904 Short-chain dehydrogenase/reductase, conserved site
      IPR002347 Short-chain dehydrogenase/reductase SDR
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 2
    • Earliest
      J:44704 Driessen CA, et al., Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997 Dec 5;203(1):27-31
    • Latest
      J:277757 Krois CR, et al., RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding. Cell Mol Life Sci. 2019 Jun;76(12):2425-2447
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory