About   Help   FAQ
Htr6 Gene Detail
Summary
  • Symbol
    Htr6
  • Name
    5-hydroxytryptamine (serotonin) receptor 6
  • Synonyms
    5-HT6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196627
    NCBI Gene: 15565
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138788419-138802881 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196627
 protein coding gene Chr4:138787017-138802881 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029010
 protein coding gene Chr4:141869278-141883572 (-)
A/J MGP_AJ_G0028969
 protein coding gene Chr4:135772715-135787076 (-)
AKR/J MGP_AKRJ_G0028921
 protein coding gene Chr4:139662958-139677321 (-)
BALB/cJ MGP_BALBcJ_G0028993
 protein coding gene Chr4:136450614-136465719 (-)
C3H/HeJ MGP_C3HHeJ_G0028707
 protein coding gene Chr4:140039023-140054676 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029434
 protein coding gene Chr4:146893991-146908360 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026705
 protein coding gene Chr4:128743772-128758605 (-)
CAST/EiJ MGP_CASTEiJ_G0028139
 protein coding gene Chr4:138218843-138235098 (-)
CBA/J MGP_CBAJ_G0028671
 protein coding gene Chr4:151121193-151135563 (-)
DBA/2J MGP_DBA2J_G0028821
 protein coding gene Chr4:136157169-136171501 (-)
FVB/NJ MGP_FVBNJ_G0028788
 protein coding gene Chr4:135189961-135205618 (-)
LP/J MGP_LPJ_G0028920
 protein coding gene Chr4:141949806-141966090 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028814
 protein coding gene Chr4:155040818-155055233 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029472
 protein coding gene Chr4:140190423-140204816 (-)
PWK/PhJ MGP_PWKPhJ_G0027860
 protein coding gene Chr4:133017406-133032038 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027685
 protein coding gene Chr4:135951563-135966042 (-)
WSB/EiJ MGP_WSBEiJ_G0028217
 protein coding gene Chr4:140438821-140453844 (-)



Homology
more
  • Human Ortholog
    HTR6, 5-hydroxytryptamine receptor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR6, 5-hydroxytryptamine receptor 6
  • Synonyms
    5-HT6, 5-HT6R
  • Links
    NCBI Gene ID: 3362
    neXtProt AC: NX_P50406
    UniProt: P50406

  • Chr Location
    1p36.13; chr1:19664875-19680966 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HTR6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for some disruptions in this gene display decreased body size. Mice homozygous for a different null allele display decreased sensitivity to alcohol induced behavioral responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    19
  • cDNA Data
    7
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028747 Ensembl Gene Model | MGI Sequence Detail 14463 C57BL/6J ±  kb
    transcript ENSMUST00000105802 Ensembl | MGI Sequence Detail 2341 Not Applicable  
    polypeptide ENSMUSP00000101428 Ensembl | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:43429 Cox GA, et al., Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 3;91(1):139-48
    • Latest
      J:332400 Dupuy V, et al., Spatiotemporal dynamics of 5-HT(6) receptor ciliary localization during mouse brain development. Neurobiol Dis. 2023 Jan;176:105949
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory