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Bcl2l11 Gene Detail
Summary
  • Symbol
    Bcl2l11
  • Name
    BCL2 like 11
  • Synonyms
    1500006F24Rik, Bim, Bod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197519
    NCBI Gene: 12125
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127967958-128004467 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.23 cM, cytoband F3-G1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    892 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197519
 protein coding gene Chr2:127967958-128004467 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026471
 protein coding gene Chr2:131443575-131481578 (+)
A/J MGP_AJ_G0026435
 protein coding gene Chr2:126125375-126161995 (+)
AKR/J MGP_AKRJ_G0026410
 protein coding gene Chr2:129717212-129753593 (+)
BALB/cJ MGP_BALBcJ_G0026447
 protein coding gene Chr2:126383463-126420301 (+)
C3H/HeJ MGP_C3HHeJ_G0026190
 protein coding gene Chr2:130227779-130264286 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026892
 protein coding gene Chr2:135559133-135595560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024269
 protein coding gene Chr2:120954174-120990717 (+)
CAST/EiJ MGP_CASTEiJ_G0025651
 protein coding gene Chr2:130440755-130479581 (+)
CBA/J MGP_CBAJ_G0026170
 protein coding gene Chr2:140581975-140618474 (+)
DBA/2J MGP_DBA2J_G0026304
 protein coding gene Chr2:125521657-125558824 (+)
FVB/NJ MGP_FVBNJ_G0026268
 protein coding gene Chr2:124166689-124204149 (+)
LP/J MGP_LPJ_G0026409
 protein coding gene Chr2:131682223-131718612 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026288
 protein coding gene Chr2:144566237-144603870 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026947
 protein coding gene Chr2:129735888-129772453 (+)
PWK/PhJ MGP_PWKPhJ_G0025387
 protein coding gene Chr2:125084521-125121851 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025189
 protein coding gene Chr2:128837400-128873819 (+)
WSB/EiJ MGP_WSBEiJ_G0025725
 protein coding gene Chr2:130646548-130683000 (+)



Homology
more
  • Human Ortholog
    BCL2L11, BCL2 like 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL2L11, BCL2 like 11
  • Synonyms
    BAM, BIM, BOD
  • Links
    NCBI Gene ID: 10018
    neXtProt AC: NX_O43521
    UniProt: O43521

  • Chr Location
    2q13; chr2:111119378-111168445 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    85 phenotypes from 14 alleles in 19 genetic backgrounds
    102 phenotypes from multigenic genotypes
    2 images
    282 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Consistent with this gene's role in hematopoietic homeostasis, homozygous null mutants accumulate lymphoid and myeloid cells and succumb to autoimmune kidney disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    21
  • cDNA Data
    22
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12125 NCBI Gene Model | MGI Sequence Detail 36510 C57BL/6J ±  kb
    transcript NM_207680 RefSeq | MGI Sequence Detail 5040 C57BL/6  
    polypeptide O54918 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 25
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1923589
    References
    more
    • Summaries
      All 447
      Developmental Gene Expression 36
      Gene Ontology 34
      Phenotypes 282
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:346017 Ou Q, et al., Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation. Cell Metab. 2024 Jan 2;36(1):78-89.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory