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Cacna1g Gene Detail
Summary
  • Symbol
    Cacna1g
  • Name
    calcium channel, voltage-dependent, T type, alpha 1G subunit
  • Synonyms
    a1G, Cav3.1d, mKIAA1123
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201678
    NCBI Gene: 12291
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94299217-94365024 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1265 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201678
 protein coding gene Chr11:94299217-94365226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018956
 protein coding gene Chr11:96499102-96569930 (-)
A/J MGP_AJ_G0018924
 protein coding gene Chr11:92638039-92706953 (-)
AKR/J MGP_AKRJ_G0018894
 protein coding gene Chr11:95518067-95591880 (-)
BALB/cJ MGP_BALBcJ_G0018897
 protein coding gene Chr11:93089176-93157403 (-)
C3H/HeJ MGP_C3HHeJ_G0018711
 protein coding gene Chr11:95605094-95674945 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019349
 protein coding gene Chr11:99504429-99577228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016980
 protein coding gene Chr11:90135029-90201689 (-)
CAST/EiJ MGP_CASTEiJ_G0018266
 protein coding gene Chr11:96314967-96390156 (-)
CBA/J MGP_CBAJ_G0018682
 protein coding gene Chr11:103634292-103716126 (-)
DBA/2J MGP_DBA2J_G0018790
 protein coding gene Chr11:92215863-92282411 (-)
FVB/NJ MGP_FVBNJ_G0018779
 protein coding gene Chr11:91636153-91704172 (-)
LP/J MGP_LPJ_G0018860
 protein coding gene Chr11:97042774-97114623 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018806
 protein coding gene Chr11:103664545-103735694 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019389
 protein coding gene Chr11:95742601-95819212 (-)
PWK/PhJ MGP_PWKPhJ_G0018036
 protein coding gene Chr11:93146889-93216169 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017826
 protein coding gene Chr11:95407845-95480753 (-)
WSB/EiJ MGP_WSBEiJ_G0018315
 protein coding gene Chr11:95628800-95699784 (-)



Homology
more
  • Human Ortholog
    CACNA1G, calcium voltage-gated channel subunit alpha1 G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNA1G, calcium voltage-gated channel subunit alpha1 G
  • Synonyms
    Cav3.1, Ca(V)T.1, NBR13, SCA42, SCA42ND
  • Links
    NCBI Gene ID: 8913
    neXtProt AC: NX_O43497
    UniProt: O43497

  • Chr Location
    17q21.33; chr17:50560715-50627474 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cacna1g mouse models; 1 with human CACNA1G associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 7 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice display disrupted sleeping patterns, altered amounts of activity, abnormal action potentials in the brain, prolonged electrical conductance in the heart, and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    59
  • cDNA Data
    59
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020866 Ensembl Gene Model | MGI Sequence Detail 65808 C57BL/6J ±  kb
    transcript ENSMUST00000107789 Ensembl | MGI Sequence Detail 8383 Not Applicable  
    polypeptide ENSMUSP00000103418 Ensembl | MGI Sequence Detail 2381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
      IPR005445 Voltage-dependent calcium channel, T-type, alpha-1 subunit
      IPR027359 Voltage-dependent channel domain superfamily
      IPR043203 Voltage-gated cation channel calcium and sodium
    • GlyGen
      Q5SUF7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 59
      Primer pair 8
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 26
      Diseases 4
      Gene Ontology 8
      Phenotypes 74
    • Earliest
      J:46135 Perez-Reyes E, et al., Molecular characterization of a neuronal low-voltage-activated T-type calcium channel [see comments]. Nature. 1998 Feb 26;391(6670):896-900
    • Latest
      J:357417 Haghbin N, et al., Functional bias of contractile control in mouse resistance arteries. Sci Rep. 2024 Oct 22;14(1):24940
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory