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Dennd5a Gene Detail
Summary
  • Symbol
    Dennd5a
  • Name
    DENN domain containing 5A
  • Synonyms
    1500012B19Rik, mKIAA1091, ORF37, Rab6ip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201681
    NCBI Gene: 19347
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109492987-109559677 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1404 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201681
 protein coding gene Chr7:109492987-109559677 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032850
 protein coding gene Chr7:113344780-113415951 (-)
A/J MGP_AJ_G0032834
 protein coding gene Chr7:110539344-110607539 (-)
AKR/J MGP_AKRJ_G0032765
 protein coding gene Chr7:113312577-113391755 (-)
BALB/cJ MGP_BALBcJ_G0032838
 protein coding gene Chr7:110238682-110306990 (-)
C3H/HeJ MGP_C3HHeJ_G0032548
 protein coding gene Chr7:113349377-113417732 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033344
 protein coding gene Chr7:118046086-118116731 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030317
 protein coding gene Chr7:112110415-112177176 (-)
CAST/EiJ MGP_CASTEiJ_G0031876
 protein coding gene Chr7:104857619-104956824 (-)
CBA/J MGP_CBAJ_G0032521
 protein coding gene Chr7:121906612-121982092 (-)
DBA/2J MGP_DBA2J_G0032673
 protein coding gene Chr7:108649132-108715447 (-)
FVB/NJ MGP_FVBNJ_G0032626
 protein coding gene Chr7:108502899-108568987 (-)
LP/J MGP_LPJ_G0032767
 protein coding gene Chr7:114881792-114950617 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032658
 protein coding gene Chr7:123562034-123640790 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033365
 protein coding gene Chr7:112325992-112398401 (-)
PWK/PhJ MGP_PWKPhJ_G0031583
 protein coding gene Chr7:101431072-101526038 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031431
 protein coding gene Chr7:98992824-99102164 (-)
WSB/EiJ MGP_WSBEiJ_G0031989
 protein coding gene Chr7:113170765-113245236 (-)



Homology
more
  • Human Ortholog
    DENND5A, DENN domain containing 5A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DENND5A, DENN domain containing 5A
  • Synonyms
    DEE49, EIEE49, RAB6IP1
  • Links
    NCBI Gene ID: 23258
    neXtProt AC: NX_Q6IQ26
    UniProt: Q6IQ26

  • Chr Location
    11p15.4; chr11:9138825-9265959 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DENND5A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    203
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19347 NCBI Gene Model | MGI Sequence Detail 66691 C57BL/6J ±  kb
transcript NM_021494 RefSeq | MGI Sequence Detail 4972 C57BL/6  
polypeptide Q6PAL8 UniProt | EBI | MGI Sequence Detail 1287 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 205
    cDNA 204
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1891747, MGI:1916213, MGI:2142242
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:303495 Iwaki A, et al., Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation. FASEB J. 2020 Jul;34(7):9450-9465
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory