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Eomes Gene Detail
Summary
  • Symbol
    Eomes
  • Name
    eomesodermin
  • Synonyms
    Tbr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201683
    NCBI Gene: 13813
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:118307259-118315176 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 70.21 cM, cytoband F3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201683
 protein coding gene Chr9:118307259-118315200 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035405
 protein coding gene Chr9:121157863-121165779 (+)
A/J MGP_AJ_G0035385
 protein coding gene Chr9:116682120-116690043 (+)
AKR/J MGP_AKRJ_G0035318
 protein coding gene Chr9:119693419-119701332 (+)
BALB/cJ MGP_BALBcJ_G0035381
 protein coding gene Chr9:116546916-116554838 (+)
C3H/HeJ MGP_C3HHeJ_G0035089
 protein coding gene Chr9:120173642-120181565 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035904
 protein coding gene Chr9:124468157-124476074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032787
 protein coding gene Chr9:113888127-113896129 (+)
CAST/EiJ MGP_CASTEiJ_G0034393
 protein coding gene Chr9:120123868-120131792 (+)
CBA/J MGP_CBAJ_G0035056
 protein coding gene Chr9:129144606-129152526 (+)
DBA/2J MGP_DBA2J_G0035215
 protein coding gene Chr9:116126565-116134505 (+)
FVB/NJ MGP_FVBNJ_G0035162
 protein coding gene Chr9:114962179-114970102 (+)
LP/J MGP_LPJ_G0035294
 protein coding gene Chr9:121505788-121513701 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035203
 protein coding gene Chr9:130189837-130197760 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035923
 protein coding gene Chr9:120078775-120086692 (+)
PWK/PhJ MGP_PWKPhJ_G0034100
 protein coding gene Chr9:116505943-116514290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033934
 protein coding gene Chr9:120165822-120173708 (+)
WSB/EiJ MGP_WSBEiJ_G0034514
 protein coding gene Chr9:119976130-119984041 (+)



Homology
more
  • Human Ortholog
    EOMES, eomesodermin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EOMES, eomesodermin
  • Synonyms
    TBR2
  • Links
    NCBI Gene ID: 8320
    neXtProt AC: NX_O95936
    UniProt: O95936

  • Chr Location
    3p24.1; chr3:27715949-27722713 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 11 alleles in 12 genetic backgrounds
    37 phenotypes from multigenic genotypes
    1 images
    146 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, fail to implant, and lack trophoectoderm outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2136
  • Tissues
    336
  • cDNA Data
    45
  • Literature Summary
    962
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13813 NCBI Gene Model | MGI Sequence Detail 7918 C57BL/6J ±  kb
    transcript NM_010136 RefSeq | MGI Sequence Detail 3689 ZRU/MplStud  
    polypeptide O54839 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 91
      Genomic 2
      cDNA 49
      Primer pair 23
      Other 17

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1313283, MGI:2143384
    References
    more
    • Summaries
      All 1157
      Developmental Gene Expression 962
      Gene Ontology 29
      Phenotypes 146
    • Earliest
      J:46272 Wattler S, et al., A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family. Genomics. 1998 Feb 15;48(1):24-33
    • Latest
      J:356256 Bertino F, et al., Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus. Cell Rep Med. 2024 Jul 16;5(7):101647
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory