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Angpt2 Gene Detail
Summary
  • Symbol
    Angpt2
  • Name
    angiopoietin 2
  • Synonyms
    Ang-2, Ang2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202890
    NCBI Gene: 11601
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:18740279-18791578 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202890
 protein coding gene Chr8:18740279-18791578 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033404
 protein coding gene Chr8:16155893-16210705 (-)
A/J MGP_AJ_G0033385
 protein coding gene Chr8:15599228-15650480 (-)
AKR/J MGP_AKRJ_G0033315
 protein coding gene Chr8:16052360-16106053 (-)
BALB/cJ MGP_BALBcJ_G0033385
 protein coding gene Chr8:15708474-15764290 (-)
C3H/HeJ MGP_C3HHeJ_G0033098
 protein coding gene Chr8:16248675-16301453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033897
 protein coding gene Chr8:16693101-16746092 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030863
 protein coding gene Chr8:14915535-14965825 (-)
CAST/EiJ MGP_CASTEiJ_G0032420
 protein coding gene Chr8:16099283-16152419 (-)
CBA/J MGP_CBAJ_G0033071
 protein coding gene Chr8:17404424-17463398 (-)
DBA/2J MGP_DBA2J_G0033225
 protein coding gene Chr8:15557555-15608649 (-)
FVB/NJ MGP_FVBNJ_G0033173
 protein coding gene Chr8:15565430-15617049 (-)
LP/J MGP_LPJ_G0033318
 protein coding gene Chr8:16178543-16233763 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033210
 protein coding gene Chr8:17573677-17629245 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033914
 protein coding gene Chr8:16078119-16130023 (-)
PWK/PhJ MGP_PWKPhJ_G0032133
 protein coding gene Chr8:15575275-15627558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031974
 protein coding gene Chr8:16000590-16051262 (-)
WSB/EiJ MGP_WSBEiJ_G0032536
 protein coding gene Chr8:16162529-16215871 (-)



Homology
more
  • Human Ortholog
    ANGPT2, angiopoietin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPT2, angiopoietin 2
  • Synonyms
    AGPT2, ANG2, LMPHM10
  • Links
    NCBI Gene ID: 285
    neXtProt AC: NX_O15123
    UniProt: O15123

  • Chr Location
    8p23.1; chr8:6499632-6563409 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ANGPT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in impaired angiogenesis, abnormal lymphatic development and function, and ultimately postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    995
  • Tissues
    176
  • cDNA Data
    32
  • Literature Summary
    93
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11601 NCBI Gene Model | MGI Sequence Detail 51300 C57BL/6J ±  kb
    transcript NM_007426 RefSeq | MGI Sequence Detail 3560 ZRU/MplStud  
    polypeptide O35608 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004024 angiopoietin-2
      (term hierarchy)
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR050373 Fibrinogen C-terminal domain-containing protein
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      O35608 6 sites, 1 N-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 33
      Primer pair 15
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 93
      Gene Ontology 15
      Phenotypes 38
    • Earliest
      J:4639 Fujisawa-Sehara A, et al., Upstream region of the myogenin gene confers transcriptional activation in muscle cell lineages during mouse embryogenesis. Biochem Biophys Res Commun. 1993 Mar 15;191(2):351-6
    • Latest
      J:354272 Pastura P, et al., NRAS(Q61R) mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model. Pediatr Blood Cancer. 2024 Jul;71(7):e31032
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory