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Bik Gene Detail
Summary
  • Symbol
    Bik
  • Name
    BCL2-interacting killer
  • Synonyms
    Biklk, Blk, Nbk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1206591
    NCBI Gene: 12124
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:83411063-83428835 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1206591
 protein coding gene Chr15:83410992-83428836 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022165
 protein coding gene Chr15:84232749-84252437 (+)
A/J MGP_AJ_G0022124
 protein coding gene Chr15:81151183-81168942 (+)
AKR/J MGP_AKRJ_G0022099
 protein coding gene Chr15:83513143-83530922 (+)
BALB/cJ MGP_BALBcJ_G0022130
 protein coding gene Chr15:81293772-81311539 (+)
C3H/HeJ MGP_C3HHeJ_G0021900
 protein coding gene Chr15:83471328-83489091 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022575
 protein coding gene Chr15:87483697-87503816 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020100
 protein coding gene Chr15:77528272-77545688 (+)
CAST/EiJ MGP_CASTEiJ_G0021422
 protein coding gene Chr15:84242057-84260109 (+)
CBA/J MGP_CBAJ_G0021867
 protein coding gene Chr15:90250891-90269097 (+)
DBA/2J MGP_DBA2J_G0021994
 protein coding gene Chr15:80634247-80652904 (+)
FVB/NJ MGP_FVBNJ_G0021973
 protein coding gene Chr15:79679542-79697684 (+)
LP/J MGP_LPJ_G0022065
 protein coding gene Chr15:84407019-84426821 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021993
 protein coding gene Chr15:95152446-95170215 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022590
 protein coding gene Chr15:83513862-83531576 (+)
PWK/PhJ MGP_PWKPhJ_G0021163
 protein coding gene Chr15:80622421-80641466 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020997
 protein coding gene Chr15:83247125-83264979 (+)
WSB/EiJ MGP_WSBEiJ_G0021471
 protein coding gene Chr15:84016250-84034308 (+)



Homology
more
  • Human Ortholog
    BIK, BCL2 interacting killer
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIK, BCL2 interacting killer
  • Synonyms
    BIP1, BP4, NBK
  • Links
    NCBI Gene ID: 638
    neXtProt AC: NX_Q13323
    UniProt: Q13323

  • Chr Location
    22q13.2; chr22:43110750-43129712 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human BIK associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    23 phenotypes from multigenic genotypes
    32 phenotype references
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Bik
  • Find Mice (IMSR)
    11 strains or lines available
Mice homozygous for a knock-out allele are viable and grossly normal with no detectable changes in hematopoiesis, lymphocyte susceptibility to various apoptotic stimuli, or endothelial cell apoptosis in hyaloid vessel regression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    9
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016758 Ensembl Gene Model | MGI Sequence Detail 17773 C57BL/6J ±  kb
transcript ENSMUST00000016902 Ensembl | MGI Sequence Detail 942 Not Applicable  
polypeptide ENSMUSP00000016902 Ensembl | MGI Sequence Detail 150 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 64
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 32
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:337771 El-Saafin F, et al., Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory