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Apba2 Gene Detail
Summary
  • Symbol
    Apba2
  • Name
    amyloid beta precursor protein binding family A member 2
  • Synonyms
    Mint 2, X11L, X11-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261791
    NCBI Gene: 11784
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:64151454-64403626 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.65 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7636 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261791
 protein coding gene Chr7:64151444-64403626 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032339
 protein coding gene Chr7:65646611-65899143 (+)
A/J MGP_AJ_G0032318
 protein coding gene Chr7:64351257-64590029 (+)
AKR/J MGP_AKRJ_G0032254
 protein coding gene Chr7:65706818-65952306 (+)
BALB/cJ MGP_BALBcJ_G0032330
 protein coding gene Chr7:64082981-64324252 (+)
C3H/HeJ MGP_C3HHeJ_G0032043
 protein coding gene Chr7:66384452-66629392 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032823
 protein coding gene Chr7:68490268-68768190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029830
 protein coding gene Chr7:67286145-67518754 (+)
CAST/EiJ MGP_CASTEiJ_G0031372
 protein coding gene Chr7:57046864-57311838 (+)
CBA/J MGP_CBAJ_G0032009
 protein coding gene Chr7:70676343-70922442 (+)
DBA/2J MGP_DBA2J_G0032165
 protein coding gene Chr7:63093882-63327233 (+)
FVB/NJ MGP_FVBNJ_G0032119
 protein coding gene Chr7:63193904-63438072 (+)
LP/J MGP_LPJ_G0032245
 protein coding gene Chr7:66895421-67140650 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032156
 protein coding gene Chr7:70943765-71206651 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032840
 protein coding gene Chr7:65022827-65283269 (+)
PWK/PhJ MGP_PWKPhJ_G0031092
 protein coding gene Chr7:56108527-56350730 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030933
 protein coding gene Chr7:52134728-52402696 (+)
WSB/EiJ MGP_WSBEiJ_G0031490
 protein coding gene Chr7:65372829-65637934 (+)



Homology
more
  • Human Ortholog
    APBA2, amyloid beta precursor protein binding family A member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APBA2, amyloid beta precursor protein binding family A member 2
  • Synonyms
    D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L
  • Links
    NCBI Gene ID: 321
    neXtProt AC: NX_Q99767
    UniProt: Q99767

  • Chr Location
    15q13.1; chr15:28884483-29118315 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show a selective deficit in motivated approach behavior, but not in motivated avoidance behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    956
  • Tissues
    120
  • cDNA Data
    27
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030519 Ensembl Gene Model | MGI Sequence Detail 252173 C57BL/6J ±  kb
    transcript ENSMUST00000032732 Ensembl | MGI Sequence Detail 3321 Not Applicable  
    polypeptide ENSMUSP00000032732 Ensembl | MGI Sequence Detail 750 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 27
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory