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Vrk1 Gene Detail
Summary
  • Symbol
    Vrk1
  • Name
    vaccinia related kinase 1
  • Synonyms
    51PK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261847
    NCBI Gene: 22367
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:105976487-106043685 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 56.37 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2002 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261847
 protein coding gene Chr12:105976398-106044578 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020097
 protein coding gene Chr12:107923883-108001585 (+)
A/J MGP_AJ_G0020051
 protein coding gene Chr12:103888068-103957323 (+)
AKR/J MGP_AKRJ_G0020027
 protein coding gene Chr12:106901923-106977342 (+)
BALB/cJ MGP_BALBcJ_G0020037
 protein coding gene Chr12:104313775-104381385 (+)
C3H/HeJ MGP_C3HHeJ_G0019839
 protein coding gene Chr12:107337030-107409320 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020482
 protein coding gene Chr12:111263092-111335483 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018094
 protein coding gene Chr12:100470719-100544457 (+)
CAST/EiJ MGP_CASTEiJ_G0019381
 protein coding gene Chr12:102150449-102225956 (+)
CBA/J MGP_CBAJ_G0019806
 protein coding gene Chr12:115690224-115762553 (+)
DBA/2J MGP_DBA2J_G0019923
 protein coding gene Chr12:103411344-103480065 (+)
FVB/NJ MGP_FVBNJ_G0019908
 protein coding gene Chr12:102194335-102265824 (+)
LP/J MGP_LPJ_G0019998
 protein coding gene Chr12:107815260-107887188 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019946
 protein coding gene Chr12:119049528-119120512 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020511
 protein coding gene Chr12:106310919-106381802 (+)
PWK/PhJ MGP_PWKPhJ_G0019140
 protein coding gene Chr12:97998120-98070756 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018944
 protein coding gene Chr12:100526420-100602870 (+)
WSB/EiJ MGP_WSBEiJ_G0019438
 protein coding gene Chr12:107260749-107330314 (+)



Homology
more
  • Human Ortholog
    VRK1, VRK serine/threonine kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VRK1, VRK serine/threonine kinase 1
  • Synonyms
    HMNR10, PCH1, PCH1A
  • Links
    NCBI Gene ID: 7443
    neXtProt AC: NX_Q99986
    UniProt: Q99986

  • Chr Location
    14q32.2; chr14:96797304-96954846 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human VRK1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a hypomorphic gene trap show progressive loss of proliferating spermatogonia, lack of meiotic cells and mature sperm and early onset sterility, whereas females show complete sterility due to defects in meiotic progression during oogenesis and failure of oocyte fertilization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    38
  • cDNA Data
    72
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021115 Ensembl Gene Model | MGI Sequence Detail 67199 C57BL/6J ±  kb
    transcript ENSMUST00000021539 Ensembl | MGI Sequence Detail 1742 Not Applicable  
    polypeptide ENSMUSP00000021539 Ensembl | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 72
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:46795 Zelko I, et al., Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys. 1998 Apr 1;352(1):31-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory