Il16 MGI Mouse Gene Detail - MGI:1270855

Symbol

Il16
Name

interleukin 16

Feature Type

protein coding gene
IDs

MGI:1270855
NCBI Gene: 16170
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr7:83292033-83394934 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 47.43 cM, cytoband D2-D3
Mapping Data

5 experiments

SNPs within 2kb

3341 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270855	protein coding gene	Chr7:83292027-83395479 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032451	protein coding gene	Chr7:85806349-85911632 (-)
A/J	MGP_AJ_G0032429	protein coding gene	Chr7:83732109-83835986 (-)
AKR/J	MGP_AKRJ_G0032365	protein coding gene	Chr7:85655967-85762992 (-)
BALB/cJ	MGP_BALBcJ_G0032441	protein coding gene	Chr7:83408606-83507978 (-)
C3H/HeJ	MGP_C3HHeJ_G0032155	protein coding gene	Chr7:86207187-86311433 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032932	protein coding gene	Chr7:89124761-89231672 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029941	protein coding gene	Chr7:86109034-86206107 (-)
CAST/EiJ	MGP_CASTEiJ_G0031482	protein coding gene	Chr7:77174244-77281867 (-)
CBA/J	MGP_CBAJ_G0032120	protein coding gene	Chr7:92114103-92218726 (-)
DBA/2J	MGP_DBA2J_G0032275	protein coding gene	Chr7:82236203-82339300 (-)
FVB/NJ	MGP_FVBNJ_G0032229	protein coding gene	Chr7:82192594-82293783 (-)
LP/J	MGP_LPJ_G0032356	protein coding gene	Chr7:87047000-87165123 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032266	protein coding gene	Chr7:92141686-92257650 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032952	protein coding gene	Chr7:85049156-85152545 (-)
PWK/PhJ	MGP_PWKPhJ_G0031202	protein coding gene	Chr7:75470121-75569687 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031044	protein coding gene	Chr7:72043828-72141823 (-)
WSB/EiJ	MGP_WSBEiJ_G0031599	protein coding gene	Chr7:85424475-85531415 (-)

Human Ortholog

IL16, interleukin 16

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL16, interleukin 16
Synonyms

LCF, NIL16, prIL-16, PRIL16
Links

HGNC:5980

NCBI Gene ID: 3603

neXtProt AC: NX_Q14005

UniProt: Q14005
Chr Location

15q25.1; chr15:81159575-81314058 (+) GRCh38

MGI Vertebrate Homology

Il16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL16
Gene Tree

Il16

Diseases

3 with human IL16 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

7
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Il16
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

54 strains or lines available

Mice homozygous for a knock-out allele display a transient but consistent increase of thymidine incorporation in anti-CD3-stimulated CD4+ T cells, but fail to show a hyperproliferative T cell phenotype using BrdU labeling.

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All GO Annotations

35
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

34
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il16

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All Sequences

67
RefSeq

17
UniProt

4
CCDS

CCDS21412.1, CCDS90266.1

Ensembl

ENSMUSG00000001741 (Evidence)
NCBI Gene

16170

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001741	Ensembl Gene Model \| MGI Sequence Detail	102902	C57BL/6J	± kb
transcript	ENSMUST00000001792	Ensembl \| MGI Sequence Detail	5260	Not Applicable
polypeptide	ENSMUSP00000001792	Ensembl \| MGI Sequence Detail	1322	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001374 pro-interleukin-16

(term hierarchy)
InterPro Domains

IPR020450 Interleukin-16

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR051890 Pro-interleukin-16
GlyGen

O54824 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 18

Genomic 1

cDNA 17

Microarray probesets 5

Summaries

All 63

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 21
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Il16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73399	Chr7:83395269-83395314 (-)	-358 bp
Tssr73398	Chr7:83395004-83395052 (-)	-94 bp
Tssr73397	Chr7:83394041-83394061 (-)	883 bp
Tssr73396	Chr7:83384742-83384751 (-)	10,187 bp
Tssr73395	Chr7:83384711-83384725 (-)	10,216 bp
Tssr73394	Chr7:83384680-83384697 (-)	10,245 bp
Tssr73393	Chr7:83384648-83384671 (-)	10,274 bp
Tssr73392	Chr7:83384634-83384644 (-)	10,295 bp
Tssr73391	Chr7:83381609-83381645 (-)	13,307 bp
Tssr73390	Chr7:83381554-83381565 (-)	13,374 bp
Tssr73389	Chr7:83355976-83355981 (-)	38,955 bp
Tssr73388	Chr7:83346771-83346776 (-)	48,160 bp
Tssr73387	Chr7:83346665-83346671 (-)	48,266 bp
Tssr73386	Chr7:83310286-83310298 (-)	84,642 bp
Tssr2319	Chr7:83308625-83308635 (-)	86,304 bp
Tssr73385	Chr7:83304699-83304706 (-)	90,231 bp
Tssr73384	Chr7:83304521-83304640 (-)	90,353 bp
Tssr73383	Chr7:83302546-83302550 (-)	92,386 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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