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Adgrv1 Gene Detail
Summary
  • Symbol
    Adgrv1
  • Name
    adhesion G protein-coupled receptor V1
  • Synonyms
    Gpr98, Mass1, Mgr1, Neurepin, VLGR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274784
    NCBI Gene: 110789
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:81243187-81781273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 42.18 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16837 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274784
 protein coding gene Chr13:81243187-81781504 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020786
 protein coding gene Chr13:81833419-82400257 (-)
A/J MGP_AJ_G0020742
 protein coding gene Chr13:78988069-79524680 (-)
AKR/J MGP_AKRJ_G0020715
 protein coding gene Chr13:81329623-81880517 (-)
BALB/cJ MGP_BALBcJ_G0020738
 protein coding gene Chr13:79536379-80070005 (-)
C3H/HeJ MGP_C3HHeJ_G0020532
 protein coding gene Chr13:81050241-81631707 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021175
 protein coding gene Chr13:84499595-85080185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018743
 protein coding gene Chr13:75495172-75993002 (-)
CAST/EiJ MGP_CASTEiJ_G0020050
 protein coding gene Chr13:80149193-80717189 (-)
CBA/J MGP_CBAJ_G0020491
 protein coding gene Chr13:87723362-88312720 (-)
DBA/2J MGP_DBA2J_G0020616
 protein coding gene Chr13:78643388-79181499 (-)
FVB/NJ MGP_FVBNJ_G0020596
 protein coding gene Chr13:77736164-78267515 (-)
LP/J MGP_LPJ_G0020689
 protein coding gene Chr13:82059131-82622963 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020625
 protein coding gene Chr13:86589250-87215889 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021215
 protein coding gene Chr13:80726794-81298935 (-)
PWK/PhJ MGP_PWKPhJ_G0019803
 protein coding gene Chr13:77544210-78096811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019626
 protein coding gene Chr13:76972227-77538582 (-)
WSB/EiJ MGP_WSBEiJ_G0020107
 protein coding gene Chr13:81177264-81730903 (-)



Homology
more
  • Human Ortholog
    ADGRV1, adhesion G protein-coupled receptor V1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRV1, adhesion G protein-coupled receptor V1
  • Synonyms
    FEB4, GPR98, MASS1, USH2B, USH2C, VLGR1, VLGR1b
  • Links
    NCBI Gene ID: 84059
    neXtProt AC: NX_Q8WXG9
    UniProt: Q8WXG9

  • Chr Location
    5q14.3; chr5:90529344-91164437 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adgrv1 mouse models; 2 with human ADGRV1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 8 alleles in 10 genetic backgrounds
    2 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells. Homozygous KO mice are deaf. Homozygosity for the c.6748Gdel deletion leads to Usher syndrome type 2C.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    79
  • cDNA Data
    53
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069170 Ensembl Gene Model | MGI Sequence Detail 538087 C57BL/6J ±  kb
    transcript ENSMUST00000095585 Ensembl | MGI Sequence Detail 19338 Not Applicable  
    polypeptide ENSMUSP00000093245 Ensembl | MGI Sequence Detail 6298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 55
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 27
      Phenotypes 43
    • Earliest
      J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5(1):305-19
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory