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Dcx Gene Detail
Summary
  • Symbol
    Dcx
  • Name
    doublecortin
  • Synonyms
    Dbct, lissencephaly, X-linked (doublecortin)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277171
    NCBI Gene: 13193
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:142638838-142716307 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 64.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1646 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277171
 protein coding gene ChrX:142638838-142716392 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036157
 protein coding gene ChrX:141419535-141498334 (-)
A/J MGP_AJ_G0036134
 protein coding gene ChrX:140743010-140826515 (-)
AKR/J MGP_AKRJ_G0036060
 protein coding gene ChrX:145302705-145380818 (-)
BALB/cJ MGP_BALBcJ_G0036125
 protein coding gene ChrX:138977802-139054170 (-)
C3H/HeJ MGP_C3HHeJ_G0035833
 protein coding gene ChrX:141496263-141576556 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036648
 protein coding gene ChrX:145366911-145466856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033472
 protein coding gene ChrX:132270396-132348231 (-)
CAST/EiJ MGP_CASTEiJ_G0035124
 protein coding gene ChrX:122191220-122270687 (-)
CBA/J MGP_CBAJ_G0035810
 protein coding gene ChrX:149932119-150008489 (-)
DBA/2J MGP_DBA2J_G0035968
 protein coding gene ChrX:139837704-139914348 (-)
FVB/NJ MGP_FVBNJ_G0035902
 protein coding gene ChrX:139032234-139110034 (-)
LP/J MGP_LPJ_G0036059
 protein coding gene ChrX:142360576-142434732 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035938
 protein coding gene ChrX:157648148-157731997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036685
 protein coding gene ChrX:140714528-140798990 (-)
PWK/PhJ MGP_PWKPhJ_G0034818
 protein coding gene ChrX:118984938-119064114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034643
 protein coding gene ChrX:122738609-122819939 (-)
WSB/EiJ MGP_WSBEiJ_G0035259
 protein coding gene ChrX:139074066-139152117 (-)



Homology
more
  • Human Ortholog
    DCX, doublecortin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCX, doublecortin
  • Synonyms
    DBCN, DC, LISX, SCLH, XLIS
  • Links
    NCBI Gene ID: 1641
    neXtProt AC: NX_O43602
    UniProt: O43602

  • Chr Location
    Xq23; chrX:111293779-111412429 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dcx mouse models; 2 with human DCX associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 5 genetic backgrounds
    43 phenotypes from multigenic genotypes
    4 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for a null allele are fertile but show branching and nucleokinesis defects in migrating interneurons. Males hemizygous for a reporter allele show severe postnatal lethality and variable fertility; both female and male mutants display hippocampal dyslamination and behavioral defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1578
  • Tissues
    342
  • cDNA Data
    208
  • Literature Summary
    374
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031285 Ensembl Gene Model | MGI Sequence Detail 77470 C57BL/6J ±  kb
    transcript ENSMUST00000087313 Ensembl | MGI Sequence Detail 3120 Not Applicable  
    polypeptide ENSMUSP00000084570 Ensembl | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 231
      cDNA 210
      Primer pair 11
      Other 10

      Microarray probesets 6
    References
    more
    • Summaries
      All 464
      Developmental Gene Expression 374
      Diseases 1
      Gene Ontology 17
      Phenotypes 40
    • Earliest
      J:48963 Sossey-Alaoui K, et al., Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects. Hum Mol Genet. 1998 Aug;7(8):1327-32
    • Latest
      J:353555 Wang W, et al., DCX knockout ferret reveals a neurogenic mechanism in cortical development. Cell Rep. 2024 Aug 27;43(8):114508
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory