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G6pc2 Gene Detail
Summary
  • Symbol
    G6pc2
  • Name
    glucose-6-phosphatase, catalytic, 2
  • Synonyms
    G6pc-rs, IGRP, islet specific glucose-6-phosphatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277193
    NCBI Gene: 14378
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69041417-69058185 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 39.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    516 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277193
 protein coding gene Chr2:69041417-69058337 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025796
 protein coding gene Chr2:69146314-69164277 (+)
A/J MGP_AJ_G0025773
 protein coding gene Chr2:66486744-66504184 (+)
AKR/J MGP_AKRJ_G0025742
 protein coding gene Chr2:68282011-68302494 (+)
BALB/cJ MGP_BALBcJ_G0025768
 protein coding gene Chr2:66665356-66682070 (+)
C3H/HeJ MGP_C3HHeJ_G0025528
 protein coding gene Chr2:68507960-68527230 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026215
 protein coding gene Chr2:71242803-71263631 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023618
 protein coding gene Chr2:63726189-63742699 (+)
CAST/EiJ MGP_CASTEiJ_G0024992
 protein coding gene Chr2:68610139-68629989 (+)
CBA/J MGP_CBAJ_G0025508
 protein coding gene Chr2:73840608-73862870 (+)
DBA/2J MGP_DBA2J_G0025639
 protein coding gene Chr2:66129454-66146205 (+)
FVB/NJ MGP_FVBNJ_G0025602
 protein coding gene Chr2:65504806-65523109 (+)
LP/J MGP_LPJ_G0025728
 protein coding gene Chr2:69008122-69026282 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025631
 protein coding gene Chr2:75903989-75921619 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026272
 protein coding gene Chr2:68363907-68381735 (+)
PWK/PhJ MGP_PWKPhJ_G0024733
 protein coding gene Chr2:65959228-65976996 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024540
 protein coding gene Chr2:68597568-68614935 (+)
WSB/EiJ MGP_WSBEiJ_G0025060
 protein coding gene Chr2:68786602-68806254 (+)



Homology
more
  • Human Ortholog
    G6PC2, glucose-6-phosphatase catalytic subunit 2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    G6PC2, glucose-6-phosphatase catalytic subunit 2
  • Synonyms
    IGRP
  • Links
    NCBI Gene ID: 57818
    neXtProt AC: NX_Q9NQR9
    UniProt: Q9NQR9

  • Chr Location
    2q31.1; chr2:168901291-168910000 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with G6pc2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption of this gene show a significant drop in fasting blood glucose. Females also show a significant drop in plasma triacylglycerol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    113
  • cDNA Data
    8
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005232 Ensembl Gene Model | MGI Sequence Detail 16769 C57BL/6J ±  kb
    transcript ENSMUST00000005364 Ensembl | MGI Sequence Detail 1892 Not Applicable  
    polypeptide ENSMUSP00000005364 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:64688 Arden SD, et al., Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42
    • Latest
      J:353482 Ortiz JA, et al., Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging. Diabetes. 2024 Sep 1;73(9):1447-1461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory