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Cxcr3 Gene Detail
Summary
  • Symbol
    Cxcr3
  • Name
    C-X-C motif chemokine receptor 3
  • Synonyms
    Cd183, Cmkar3, Cxcr3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277207
    NCBI Gene: 12766
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100775141-100777753 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 44.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277207
 protein coding gene ChrX:100775141-100777875 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035965
 protein coding gene ChrX:98273825-98276556 (-)
A/J MGP_AJ_G0035950
 protein coding gene ChrX:98252052-98254786 (-)
AKR/J MGP_AKRJ_G0035866
 protein coding gene ChrX:101088820-101091552 (-)
BALB/cJ MGP_BALBcJ_G0035933
 protein coding gene ChrX:96998533-97001267 (-)
C3H/HeJ MGP_C3HHeJ_G0035642
 protein coding gene ChrX:98672925-98675659 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036463
 protein coding gene ChrX:101179434-101183026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033292
 protein coding gene ChrX:95982071-95984803 (-)
CAST/EiJ MGP_CASTEiJ_G0034929
 protein coding gene ChrX:82964718-82967452 (-)
CBA/J MGP_CBAJ_G0035617
 protein coding gene ChrX:104320667-104323398 (-)
DBA/2J MGP_DBA2J_G0035771
 protein coding gene ChrX:97462151-97465094 (-)
FVB/NJ MGP_FVBNJ_G0035710
 protein coding gene ChrX:96846474-96849205 (-)
LP/J MGP_LPJ_G0035862
 protein coding gene ChrX:99209455-99212202 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035744
 protein coding gene ChrX:108855028-108857762 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036489
 protein coding gene ChrX:97943376-97946888 (-)
PWK/PhJ MGP_PWKPhJ_G0034628
 protein coding gene ChrX:80567674-80570407 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034456
 protein coding gene ChrX:83887608-83890339 (-)
WSB/EiJ MGP_WSBEiJ_G0035068
 protein coding gene ChrX:96649801-96652534 (-)



Homology
more
  • Human Ortholog
    CXCR3, C-X-C motif chemokine receptor 3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCR3, C-X-C motif chemokine receptor 3
  • Synonyms
    CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR
  • Links
    NCBI Gene ID: 2833
    neXtProt AC: NX_P49682
    UniProt: P49682

  • Chr Location
    Xq13.1; chrX:71615916-71618511 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CXCR3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    204 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for disruptions in this gene display immune system abnormalities. Hemizygous male mice exhibit elevated serum glucose levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    51
  • cDNA Data
    7
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12766 NCBI Gene Model | MGI Sequence Detail 2613 C57BL/6J ±  kb
    transcript NM_009910 RefSeq | MGI Sequence Detail 1609 ZRU/MplStud  
    polypeptide O88410 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 7
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 285
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 204
    • Earliest
      J:48732 Soto H, et al., The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10
    • Latest
      J:352246 Guo K, et al., The chemokine receptor CXCR3 promotes CD8(+) T cell-dependent lung pathology during influenza pathogenesis. Sci Adv. 2024 Jan 5;10(1):eadj1120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory