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Sap18 Gene Detail
Summary
  • Symbol
    Sap18
  • Name
    Sin3-associated polypeptide 18
  • Synonyms
    C530046K05Rik, D11Ertd539e, EMegR4, Sap18a, Sinbp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277978
    NCBI Gene: 20220
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:58035646-58042437 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277978
 protein coding gene Chr14:58035637-58044095 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021411
 protein coding gene Chr14:52016487-52023287 (+)
A/J MGP_AJ_G0021372
 protein coding gene Chr14:50968580-50975380 (+)
AKR/J MGP_AKRJ_G0021347
 protein coding gene Chr14:52762586-52769591 (+)
BALB/cJ MGP_BALBcJ_G0021375
 protein coding gene Chr14:50910797-50919118 (+)
C3H/HeJ MGP_C3HHeJ_G0021154
 protein coding gene Chr14:52415816-52422799 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021814
 protein coding gene Chr14:54567386-54575522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019354
 protein coding gene Chr14:49053520-49060228 (+)
CAST/EiJ MGP_CASTEiJ_G0020672
 protein coding gene Chr14:48758633-48765415 (+)
CBA/J MGP_CBAJ_G0021121
 protein coding gene Chr14:56195092-56201892 (+)
DBA/2J MGP_DBA2J_G0021242
 protein coding gene Chr14:50642975-50650282 (+)
FVB/NJ MGP_FVBNJ_G0021223
 protein coding gene Chr14:50035114-50043271 (+)
LP/J MGP_LPJ_G0021317
 protein coding gene Chr14:53050582-53057889 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021251
 protein coding gene Chr14:55531792-55538884 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021838
 protein coding gene Chr14:51907572-51914372 (+)
PWK/PhJ MGP_PWKPhJ_G0020415
 protein coding gene Chr14:47188863-47195784 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020248
 protein coding gene Chr14:47991128-47997906 (+)
WSB/EiJ MGP_WSBEiJ_G0020724
 protein coding gene Chr14:52226709-52233509 (+)



Homology
more
  • Human Ortholog
    SAP18, Sin3A associated protein 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAP18, Sin3A associated protein 18
  • Synonyms
    2HOR0202, SAP18P
  • Links
    NCBI Gene ID: 10284
    neXtProt AC: NX_O00422
    UniProt: O00422

  • Chr Location
    13q12.11; chr13:21140119-21149097 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Sap18
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    58
  • cDNA Data
    24
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20220 NCBI Gene Model | MGI Sequence Detail 6792 C57BL/6J ±  kb
transcript NM_009119 RefSeq | MGI Sequence Detail 3472 ZRU/MplStud  
polypeptide O55128 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1203397, MGI:1261774, MGI:2443909
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:46097 Boehmelt G, et al., Cloning of the murine transcriptional corepressor component SAP18 and differential expression of its mRNA in the hematopoietic hierarchy. Gene. 1998 Jan 30;207(2):267-75
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory