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Lrp5 Gene Detail
Summary
  • Symbol
    Lrp5
  • Name
    low density lipoprotein receptor-related protein 5
  • Synonyms
    LR3, LRP7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278315
    NCBI Gene: 16973
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:3634828-3736564 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.33 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278315
 protein coding gene Chr19:3634825-3736574 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024627
 protein coding gene Chr19:349117-464791 (-)
A/J MGP_AJ_G0024594
 protein coding gene Chr19:355342-458820 (-)
AKR/J MGP_AKRJ_G0024565
 protein coding gene Chr19:344655-454271 (-)
BALB/cJ MGP_BALBcJ_G0024592
 protein coding gene Chr19:339503-445919 (-)
C3H/HeJ MGP_C3HHeJ_G0024361
 protein coding gene Chr19:347798-454994 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025040
 protein coding gene Chr19:339330-458617 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022469
 protein coding gene Chr19:331019-436758 (-)
CAST/EiJ MGP_CASTEiJ_G0023833
 protein coding gene Chr19:356170-467375 (-)
CBA/J MGP_CBAJ_G0024331
 protein coding gene Chr19:385902-510624 (-)
DBA/2J MGP_DBA2J_G0024460
 protein coding gene Chr19:334347-436595 (-)
FVB/NJ MGP_FVBNJ_G0024427
 protein coding gene Chr19:338623-441843 (-)
LP/J MGP_LPJ_G0024546
 protein coding gene Chr19:348455-469079 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024457
 protein coding gene Chr19:376299-485773 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025088
 protein coding gene Chr19:342401-452224 (-)
PWK/PhJ MGP_PWKPhJ_G0023579
 protein coding gene Chr19:346973-454640 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023385
 protein coding gene Chr19:343599-460154 (-)
WSB/EiJ MGP_WSBEiJ_G0023896
 protein coding gene Chr19:343261-450346 (-)



Homology
more
  • Human Ortholog
    LRP5, LDL receptor related protein 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRP5, LDL receptor related protein 5
  • Synonyms
    BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP-7, LRP7, OPPG, OPS, OPTA1, PCLD4, VBCH2
  • Links
    NCBI Gene ID: 4041
    neXtProt AC: NX_O75197
    UniProt: O75197

  • Chr Location
    11q13.2; chr11:68298412-68449275 (+)  GRCh38
  • Human Ortholog
    LRP5L, LDL receptor related protein 5 like (pseudogene)
  • Links
    NCBI Gene ID: 91355
    neXtProt AC: NX_A4QPB2
    UniProt: A4QPB2

  • Chr Location
    22q11.23; chr22:25351418-25405408 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Lrp5 mouse models; 11 with human LRP5 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    91 phenotypes from 24 alleles in 23 genetic backgrounds
    62 phenotypes from multigenic genotypes
    7 images
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background. Homozygous knockout or ineducible KO in endothelial cells affects retinal angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1261
  • Tissues
    371
  • cDNA Data
    84
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024913 Ensembl Gene Model | MGI Sequence Detail 101737 C57BL/6J ±  kb
    transcript ENSMUST00000025856 Ensembl | MGI Sequence Detail 5161 Not Applicable  
    polypeptide ENSMUSP00000025856 Ensembl | MGI Sequence Detail 1614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009925 low-density lipoprotein receptor-related protein 5
      (term hierarchy)
    • InterPro Domains
      IPR050778 Cueball/EGF/LRP/Nidogen
      IPR000742 EGF-like domain
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR017049 Low density lipoprotein receptor-related protein 5/6
      IPR011042 Six-bladed beta-propeller, TolB-like
    • GlyGen
      Q91VN0 8 sites, 1 N-linked glycan (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 1
      cDNA 84
      Primer pair 10
      Other 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 49
      Diseases 5
      Gene Ontology 34
      Phenotypes 117
    • Earliest
      J:49544 Hey PJ, et al., Cloning of a novel member of the low-density lipoprotein receptor family. Gene. 1998 Aug 17;216(1):103-11
    • Latest
      J:348747 Kim G, et al., Gut-liver axis calibrates intestinal stem cell fitness. Cell. 2024 Feb 15;187(4):914-930.e20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory