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Setd3 Gene Detail
Summary
  • Symbol
    Setd3
  • Name
    SET domain containing 3
  • Synonyms
    2610102I01Rik, 2610305M23Rik, D12Ertd771e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289184
    NCBI Gene: 52690
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108072690-108145573 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.23 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1626 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289184
 protein coding gene Chr12:108072690-108145616 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020100
 protein coding gene Chr12:110169653-110261438 (-)
A/J MGP_AJ_G0020054
 protein coding gene Chr12:106037101-106108927 (-)
AKR/J MGP_AKRJ_G0020030
 protein coding gene Chr12:109101541-109176474 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0019842
 protein coding gene Chr12:109542915-109617549 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020485
 protein coding gene Chr12:113572038-113650643 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018097
 protein coding gene Chr12:102568052-102642611 (-)
CAST/EiJ MGP_CASTEiJ_G0019384
 protein coding gene Chr12:104460925-104538801 (-)
CBA/J MGP_CBAJ_G0019809
 protein coding gene Chr12:118083596-118159673 (-)
DBA/2J MGP_DBA2J_G0019926
 protein coding gene Chr12:105552622-105631695 (-)
FVB/NJ MGP_FVBNJ_G0019911
 protein coding gene Chr12:104334671-104409923 (-)
LP/J MGP_LPJ_G0020001
 protein coding gene Chr12:110054017-110140252 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019949
 protein coding gene Chr12:121287350-121387742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020514
 protein coding gene Chr12:108553385-108632491 (-)
PWK/PhJ MGP_PWKPhJ_G0019143
 protein coding gene Chr12:100167855-100241632 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018947
 protein coding gene Chr12:102769469-102846566 (-)
WSB/EiJ MGP_WSBEiJ_G0019441
 protein coding gene Chr12:109510513-109576188 (-)



Homology
more
  • Human Ortholog
    SETD3, SET domain containing 3, actin N3(tau)-histidine methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SETD3, SET domain containing 3, actin N3(tau)-histidine methyltransferase
  • Synonyms
    C14orf154, hSETD3
  • Links
    NCBI Gene ID: 84193
    neXtProt AC: NX_Q86TU7
    UniProt: Q86TU7

  • Chr Location
    14q32.2; chr14:99397748-99486458 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired migration of MEFs, reduced litter size from female mice and primary dystocia. Homozygous KO also protects against enterovirus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056770 Ensembl Gene Model | MGI Sequence Detail 72884 C57BL/6J ±  kb
    transcript ENSMUST00000071095 Ensembl | MGI Sequence Detail 2755 Not Applicable  
    polypeptide ENSMUSP00000066413 Ensembl | MGI Sequence Detail 594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919723, MGI:1919763
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory