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Eipr1 Gene Detail
Summary
  • Symbol
    Eipr1
  • Name
    EARP complex and GARP complex interacting protein 1
  • Synonyms
    D12Ertd604e, Tssc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289332
    NCBI Gene: 380752
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:28801802-28917493 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 11.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289332
 protein coding gene Chr12:28801802-28919864 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019647
 protein coding gene Chr12:26594130-26714066 (+)
A/J MGP_AJ_G0019614
 protein coding gene Chr12:25880807-25995145 (+)
AKR/J MGP_AKRJ_G0019585
 protein coding gene Chr12:26752337-26869624 (+)
BALB/cJ MGP_BALBcJ_G0019591
 protein coding gene Chr12:26128422-26245132 (+)
C3H/HeJ MGP_C3HHeJ_G0019395
 protein coding gene Chr12:26597415-26715941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020038
 protein coding gene Chr12:27449141-27573473 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017663
 protein coding gene Chr12:25230614-25348530 (+)
CAST/EiJ MGP_CASTEiJ_G0018950
 protein coding gene Chr12:21560858-21673011 (+)
CBA/J MGP_CBAJ_G0019366
 protein coding gene Chr12:28418312-28537144 (+)
DBA/2J MGP_DBA2J_G0019480
 protein coding gene Chr12:25730050-25843536 (+)
FVB/NJ MGP_FVBNJ_G0019471
 protein coding gene Chr12:25531340-25644591 (+)
LP/J MGP_LPJ_G0019550
 protein coding gene Chr12:26682873-26804555 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019506
 protein coding gene Chr12:28045318-28167153 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020078
 protein coding gene Chr12:26261980-26377001 (+)
PWK/PhJ MGP_PWKPhJ_G0018717
 protein coding gene Chr12:20434618-20553042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018505
 protein coding gene Chr12:20844164-20963315 (+)
WSB/EiJ MGP_WSBEiJ_G0019001
 protein coding gene Chr12:26458993-26578773 (+)



Homology
more
  • Human Ortholog
    EIPR1, EARP complex and GARP complex interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIPR1, EARP complex and GARP complex interacting protein 1
  • Synonyms
    EIPR-1, TSSC1
  • Links
    NCBI Gene ID: 7260
    neXtProt AC: NX_Q53HC9
    UniProt: Q53HC9

  • Chr Location
    2p25.3; chr2:3188925-3377830 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    9
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 380752 NCBI Gene Model | MGI Sequence Detail 115692 C57BL/6J ±  kb
    transcript NM_001379229 RefSeq | MGI Sequence Detail 1783 ZRU/MplStud  
    polypeptide Q8K0G5 UniProt | EBI | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:5911411
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory