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Itgae Gene Detail
Summary
  • Symbol
    Itgae
  • Name
    integrin alpha E, epithelial-associated
  • Synonyms
    alpha-E1, CD103
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298377
    NCBI Gene: 16407
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72981409-73038272 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    532 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298377
 protein coding gene Chr11:72981396-73038272 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018651
 protein coding gene Chr11:73761403-73825042 (+)
A/J MGP_AJ_G0018619
 protein coding gene Chr11:70991750-71054064 (+)
AKR/J MGP_AKRJ_G0018588
 protein coding gene Chr11:73158093-73221536 (+)
BALB/cJ MGP_BALBcJ_G0018591
 protein coding gene Chr11:71296253-71355332 (+)
C3H/HeJ MGP_C3HHeJ_G0018404
 protein coding gene Chr11:73115705-73177203 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019042
 protein coding gene Chr11:75991727-76074245 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016685
 protein coding gene Chr11:67801996-67860045 (+)
CAST/EiJ MGP_CASTEiJ_G0017959
 protein coding gene Chr11:73496843-73558952 (+)
CBA/J MGP_CBAJ_G0018376
 protein coding gene Chr11:79360793-79423117 (+)
DBA/2J MGP_DBA2J_G0018485
 protein coding gene Chr11:70621878-70678522 (+)
FVB/NJ MGP_FVBNJ_G0018476
 protein coding gene Chr11:70168162-70228378 (+)
LP/J MGP_LPJ_G0018556
 protein coding gene Chr11:74259065-74321422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018499
 protein coding gene Chr11:79876530-79937504 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019084
 protein coding gene Chr11:73348693-73407212 (+)
PWK/PhJ MGP_PWKPhJ_G0017732
 protein coding gene Chr11:71258865-71320150 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017522
 protein coding gene Chr11:73061239-73125002 (+)
WSB/EiJ MGP_WSBEiJ_G0018013
 protein coding gene Chr11:73096262-73154406 (+)



Homology
more
  • Human Ortholog
    ITGAE, integrin subunit alpha E
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAE, integrin subunit alpha E
  • Synonyms
    CD103, HUMINAE
  • Links
    NCBI Gene ID: 3682
    neXtProt AC: NX_P38570
    UniProt: P38570

  • Chr Location
    17p13.2; chr17:3714628-3801188 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    15
  • cDNA Data
    20
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005947 Ensembl Gene Model | MGI Sequence Detail 56864 C57BL/6J ±  kb
transcript ENSMUST00000006101 Ensembl | MGI Sequence Detail 3845 Not Applicable  
polypeptide ENSMUSP00000006101 Ensembl | MGI Sequence Detail 1167 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 130
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 61
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory