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Map1a Gene Detail
Summary
  • Symbol
    Map1a
  • Name
    microtubule-associated protein 1 A
  • Synonyms
    6330416M19Rik, Mtap-1, Mtap1, Mtap1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306776
    NCBI Gene: 17754
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121120081-121141313 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.37 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    351 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306776
 protein coding gene Chr2:121119608-121141313 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026386
 protein coding gene Chr2:124175583-124196882 (+)
A/J MGP_AJ_G0026347
 protein coding gene Chr2:119103012-119124331 (+)
AKR/J MGP_AKRJ_G0026326
 protein coding gene Chr2:122445569-122468625 (+)
BALB/cJ MGP_BALBcJ_G0026360
 protein coding gene Chr2:119335394-119356952 (+)
C3H/HeJ MGP_C3HHeJ_G0026106
 protein coding gene Chr2:122925654-122947533 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026807
 protein coding gene Chr2:128246377-128267608 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024187
 protein coding gene Chr2:114145712-114167000 (+)
CAST/EiJ MGP_CASTEiJ_G0025568
 protein coding gene Chr2:123248767-123272040 (+)
CBA/J MGP_CBAJ_G0026082
 protein coding gene Chr2:132715484-132736724 (+)
DBA/2J MGP_DBA2J_G0026221
 protein coding gene Chr2:118497899-118519104 (+)
FVB/NJ MGP_FVBNJ_G0026183
 protein coding gene Chr2:117317590-117340363 (+)
LP/J MGP_LPJ_G0026322
 protein coding gene Chr2:124434424-124456011 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026202
 protein coding gene Chr2:136997113-137018331 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026862
 protein coding gene Chr2:122560340-122581580 (+)
PWK/PhJ MGP_PWKPhJ_G0025304
 protein coding gene Chr2:118108858-118130434 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025103
 protein coding gene Chr2:121771876-121793300 (+)
WSB/EiJ MGP_WSBEiJ_G0025637
 protein coding gene Chr2:123388314-123409597 (+)



Homology
more
  • Human Ortholog
    MAP1A, microtubule associated protein 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP1A, microtubule associated protein 1A
  • Synonyms
    MAP1L, MTAP1A
  • Links
    NCBI Gene ID: 4130
    neXtProt AC: NX_P78559
    UniProt: P78559

  • Chr Location
    15q15.3; chr15:43510954-43531620 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit Purkinje cell degeneration. Mice homozygous for a spontaneous mutation exhibit mild ataxia and Purkinje cell degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    4
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027254 Ensembl Gene Model | MGI Sequence Detail 21233 C57BL/6J ±  kb
    transcript ENSMUST00000094639 Ensembl | MGI Sequence Detail 11825 Not Applicable  
    polypeptide ENSMUSP00000092223 Ensembl | MGI Sequence Detail 3014 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010116 microtubule-associated protein 1A
      (term hierarchy)
    • PDB
      5GNV
    • InterPro Domains
      IPR026074 Microtubule associated protein 1
      IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
    • GlyGen
      Q9QYR6 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12579, MGD-MRK-12584, MGI:1346024, MGI:1921253, MGI:2139097, MGI:97174
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:298726 Argent L, et al., Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology. J Biol Chem. 2020 Sep 4;295(36):12716-12726
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory