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Itgb1bp1 Gene Detail
Summary
  • Symbol
    Itgb1bp1
  • Name
    integrin beta 1 binding protein 1
  • Synonyms
    bodenin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306802
    NCBI Gene: 16413
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:21317247-21336285 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    545 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306802
 protein coding gene Chr12:21290826-21336285 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019622
 protein coding gene Chr12:18819649-18839460 (-)
A/J MGP_AJ_G0019589
 protein coding gene Chr12:18113285-18130218 (-)
AKR/J MGP_AKRJ_G0019560
 protein coding gene Chr12:18947071-18964533 (-)
BALB/cJ MGP_BALBcJ_G0019566
 protein coding gene Chr12:18488078-18504277 (-)
C3H/HeJ MGP_C3HHeJ_G0019370
 protein coding gene Chr12:18838518-18861317 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0017639
 protein coding gene Chr12:17712341-17730657 (-)
CAST/EiJ MGP_CASTEiJ_G0018925
 protein coding gene Chr12:16113057-16130440 (-)
CBA/J MGP_CBAJ_G0019342
 protein coding gene Chr12:20252449-20272230 (-)
DBA/2J MGP_DBA2J_G0019455
 protein coding gene Chr12:18146004-18162579 (-)
FVB/NJ MGP_FVBNJ_G0019446
 protein coding gene Chr12:18047580-18063811 (-)
LP/J MGP_LPJ_G0019525
 protein coding gene Chr12:18920889-18939133 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019481
 protein coding gene Chr12:20075347-20095891 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020053
 protein coding gene Chr12:18522954-18541976 (-)
PWK/PhJ MGP_PWKPhJ_G0018691
 protein coding gene Chr12:15415466-15431952 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018480
 protein coding gene Chr12:15810038-15830345 (-)
WSB/EiJ MGP_WSBEiJ_G0018976
 protein coding gene Chr12:18707270-18724726 (-)



Homology
more
  • Human Ortholog
    ITGB1BP1, integrin subunit beta 1 binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB1BP1, integrin subunit beta 1 binding protein 1
  • Synonyms
    ICAP1, ICAP-1A, ICAP1A, ICAP-1alpha, ICAP-1B, ICAP1B
  • Links
    NCBI Gene ID: 9270
    neXtProt AC: NX_O14713
    UniProt: O14713

  • Chr Location
    2p25.1; chr2:9403475-9423569 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, reduced weight and length, reduced ossification, and skull and skeleton abnormalities. Mice homozygous for a gene trap mutation are viable and do not exhibit any obvious abnormalites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    2
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16413 NCBI Gene Model | MGI Sequence Detail 19039 C57BL/6J ±  kb
    transcript NM_001355609 RefSeq | MGI Sequence Detail 2192 C57BL/6  
    polypeptide O35671 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2144827, MGI:2144948
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:47964 Faisst AM, et al., Bodenin: a novel murine gene expressed in restricted areas of the brain. Dev Dyn. 1998 Jun;212(2):293-303
    • Latest
      J:201629 Faurobert E, et al., CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial contractility and fibronectin remodeling. J Cell Biol. 2013 Aug 5;202(3):545-61
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory