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Tpst2 Gene Detail
Summary
  • Symbol
    Tpst2
  • Name
    protein-tyrosine sulfotransferase 2
  • Synonyms
    D5Ucla3, grm, grt, Tango13b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309516
    NCBI Gene: 22022
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:112424557-112463227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 54.65 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1065 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309516
 protein coding gene Chr5:112424548-112463227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029902
 protein coding gene Chr5:114849948-114892110 (+)
A/J MGP_AJ_G0029868
 protein coding gene Chr5:110379332-110418824 (+)
AKR/J MGP_AKRJ_G0029806
 protein coding gene Chr5:113885957-113924599 (+)
BALB/cJ MGP_BALBcJ_G0029879
 protein coding gene Chr5:111738303-111779171 (+)
C3H/HeJ MGP_C3HHeJ_G0029599
 protein coding gene Chr5:114327548-114368533 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030332
 protein coding gene Chr5:119337489-119383204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027561
 protein coding gene Chr5:105203072-105241427 (+)
CAST/EiJ MGP_CASTEiJ_G0029007
 protein coding gene Chr5:113226951-113270078 (+)
CBA/J MGP_CBAJ_G0029566
 protein coding gene Chr5:123814622-123859189 (+)
DBA/2J MGP_DBA2J_G0029716
 protein coding gene Chr5:110445546-110485588 (+)
FVB/NJ MGP_FVBNJ_G0029673
 protein coding gene Chr5:109168151-109209713 (+)
LP/J MGP_LPJ_G0029804
 protein coding gene Chr5:115417757-115459286 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029704
 protein coding gene Chr5:128393631-128436679 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030373
 protein coding gene Chr5:113320302-113359235 (+)
PWK/PhJ MGP_PWKPhJ_G0028721
 protein coding gene Chr5:109054324-109094212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028559
 protein coding gene Chr5:110806341-110844720 (+)
WSB/EiJ MGP_WSBEiJ_G0029083
 protein coding gene Chr5:113833234-113875944 (+)



Homology
more
  • Human Ortholog
    TPST2, tyrosylprotein sulfotransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPST2, tyrosylprotein sulfotransferase 2
  • Synonyms
    TANGO13B, TPST-2
  • Links
    NCBI Gene ID: 8459
    neXtProt AC: NX_O60704
    UniProt: O60704

  • Chr Location
    22q12.1; chr22:26521996-26596717 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Spontaneous mutants show a delayed rise and a prolonged deficit of pituitary growth hormone resulting in delayed pubertal growth, hypothyroidism, and an enlarged adenohypophysis with aberrant chromophobic cells. Homozygous null mice show a modest but transient pubertal growth lag and male sterility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029344 Ensembl Gene Model | MGI Sequence Detail 38671 C57BL/6J ±  kb
    transcript ENSMUST00000239473 Ensembl | MGI Sequence Detail 1813 Not Applicable  
    polypeptide ENSMUSP00000159350 Ensembl | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 1
      cDNA 76
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16734, MGD-MRK-7379, MGI:2140887, MGI:93474, MGI:99932
    References
    more
    • Summaries
      All 74
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:338109 Dai D, et al., Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis. BMC Biol. 2023 Jul 10;21(1):151
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory