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Hk2 Gene Detail
Summary
  • Symbol
    Hk2
  • Name
    hexokinase 2
  • Synonyms
    HKII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315197
    NCBI Gene: 15277
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:82702006-82751435 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    668 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315197
 protein coding gene Chr6:82702004-82751437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030906
 protein coding gene Chr6:83704653-83757454 (-)
A/J MGP_AJ_G0030875
 protein coding gene Chr6:80510473-80559689 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0030885
 protein coding gene Chr6:80524241-80573688 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0031345
 protein coding gene Chr6:85971729-86023093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028531
 protein coding gene Chr6:78864989-78913663 (-)
CAST/EiJ MGP_CASTEiJ_G0029994
 protein coding gene Chr6:82804308-82866630 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0030725
 protein coding gene Chr6:79832084-79880521 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0030714
 protein coding gene Chr6:93694877-93750290 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031369
 protein coding gene Chr6:82635159-82687974 (-)
PWK/PhJ MGP_PWKPhJ_G0029709
 protein coding gene Chr6:78717430-78767607 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029537
 protein coding gene Chr6:81499194-81548462 (-)
WSB/EiJ MGP_WSBEiJ_G0030075
 protein coding gene Chr6:83078910-83128057 (-)



Homology
more
  • Human Ortholog
    HK2, hexokinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HK2, hexokinase 2
  • Synonyms
    HKII, HXK2
  • Links
    NCBI Gene ID: 3099
    neXtProt AC: NX_P52789
    UniProt: P52789

  • Chr Location
    2p12; chr2:74834127-74893359 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HK2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out mutation are severely growth retarded and die around E8.5. Interestingly, heterozygous mutant mice are viable and fertile, develop normally and do not exhibit impaired insulin action or glucose tolerance even when challenged with a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    137
  • cDNA Data
    10
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000628 Ensembl Gene Model | MGI Sequence Detail 49430 C57BL/6J ±  kb
    transcript ENSMUST00000000642 Ensembl | MGI Sequence Detail 5513 Not Applicable  
    polypeptide ENSMUSP00000000642 Ensembl | MGI Sequence Detail 917 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 5
      cDNA 11
      Primer pair 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141455
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 16
      Phenotypes 41
    • Earliest
      J:34217 Tsao TS, et al., Regulation of hexokinase II gene expression by glucose flux in skeletal muscle. J Biol Chem. 1996 Jun 21;271(25):14959-63
    • Latest
      J:352101 Codocedo JF, et al., Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer's progression. Cell Rep. 2024 Jul 23;43(7):114488
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory