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Sphk1 Gene Detail
Summary
  • Symbol
    Sphk1
  • Name
    sphingosine kinase 1
  • Synonyms
    1110006G24Rik, SK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316649
    NCBI Gene: 20698
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116421751-116427501 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.42 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316649
 protein coding gene Chr11:116421662-116427502 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019430
 protein coding gene Chr11:120665620-120671365 (+)
A/J MGP_AJ_G0019398
 protein coding gene Chr11:115382786-115388533 (+)
AKR/J MGP_AKRJ_G0019369
 protein coding gene Chr11:118817432-118823181 (+)
BALB/cJ MGP_BALBcJ_G0019373
 protein coding gene Chr11:115782391-115788136 (+)
C3H/HeJ MGP_C3HHeJ_G0019179
 protein coding gene Chr11:119174210-119179957 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019822
 protein coding gene Chr11:124347360-124353109 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017446
 protein coding gene Chr11:112381990-112387701 (+)
CAST/EiJ MGP_CASTEiJ_G0018734
 protein coding gene Chr11:120549394-120555146 (+)
CBA/J MGP_CBAJ_G0019150
 protein coding gene Chr11:129276971-129282718 (+)
DBA/2J MGP_DBA2J_G0019262
 protein coding gene Chr11:114811730-114817475 (+)
FVB/NJ MGP_FVBNJ_G0019254
 protein coding gene Chr11:114313861-114319606 (+)
LP/J MGP_LPJ_G0019332
 protein coding gene Chr11:121048843-121054618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019287
 protein coding gene Chr11:128314194-128319939 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019861
 protein coding gene Chr11:119482008-119487753 (+)
PWK/PhJ MGP_PWKPhJ_G0018498
 protein coding gene Chr11:116135792-116141620 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018291
 protein coding gene Chr11:119230241-119235971 (+)
WSB/EiJ MGP_WSBEiJ_G0018786
 protein coding gene Chr11:119445589-119453625 (+)



Homology
more
  • Human Ortholog
    SPHK1, sphingosine kinase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPHK1, sphingosine kinase 1
  • Synonyms
    SPHK
  • Links
    NCBI Gene ID: 8877
    neXtProt AC: NX_Q9NYA1
    UniProt: Q9NYA1

  • Chr Location
    17q25.1; chr17:76376584-76387860 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SPHK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 5 genetic backgrounds
    35 phenotypes from multigenic genotypes
    2 images
    140 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable, fertile, and without any obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    27
  • cDNA Data
    50
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061878 Ensembl Gene Model | MGI Sequence Detail 5751 C57BL/6J ±  kb
    transcript ENSMUST00000141798 Ensembl | MGI Sequence Detail 1537 Not Applicable  
    polypeptide ENSMUSP00000131010 Ensembl | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 54
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913372
    References
    more
    • Summaries
      All 240
      Developmental Gene Expression 14
      Gene Ontology 20
      Phenotypes 140
    • Earliest
      J:49744 Kohama T, et al., Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem. 1998 Sep 11;273(37):23722-8
    • Latest
      J:359015 Li R, et al., miR-495 promotes intestinal epithelial cell apoptosis through downregulation of Sphingosine-1-phosphate. Physiol Rep. 2024 Sep;12(17):e70021
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory