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Nfs1 Gene Detail
Summary
  • Symbol
    Nfs1
  • Name
    nitrogen fixation gene 1 (S. cerevisiae)
  • Synonyms
    m-Nfs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316706
    NCBI Gene: 18041
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155965569-155986106 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    580 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316706
 protein coding gene Chr2:155965559-155986106 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026758
 protein coding gene Chr2:160980037-161006257 (-)
A/J MGP_AJ_G0026724
 protein coding gene Chr2:154590454-154619349 (-)
AKR/J MGP_AKRJ_G0026695
 protein coding gene Chr2:159080046-159102059 (-)
BALB/cJ MGP_BALBcJ_G0026733
 protein coding gene Chr2:154884809-154904643 (-)
C3H/HeJ MGP_C3HHeJ_G0026476
 protein coding gene Chr2:159440460-159461523 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027182
 protein coding gene Chr2:165714675-165736311 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024552
 protein coding gene Chr2:148087206-148104235 (-)
CAST/EiJ MGP_CASTEiJ_G0025937
 protein coding gene Chr2:159767568-159789918 (-)
CBA/J MGP_CBAJ_G0026453
 protein coding gene Chr2:171737569-171760842 (-)
DBA/2J MGP_DBA2J_G0026590
 protein coding gene Chr2:153766866-153791030 (-)
FVB/NJ MGP_FVBNJ_G0026557
 protein coding gene Chr2:152142443-152164445 (-)
LP/J MGP_LPJ_G0026695
 protein coding gene Chr2:161119260-161140367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026578
 protein coding gene Chr2:175682704-175708767 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027238
 protein coding gene Chr2:158953977-158976341 (-)
PWK/PhJ MGP_PWKPhJ_G0025671
 protein coding gene Chr2:153269203-153291795 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025474
 protein coding gene Chr2:157899961-157916188 (-)
WSB/EiJ MGP_WSBEiJ_G0026007
 protein coding gene Chr2:159843369-159865342 (-)



Homology
more
  • Human Ortholog
    NFS1, NFS1 cysteine desulfurase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFS1, NFS1 cysteine desulfurase
  • Synonyms
    COXPD52, HUSSY-08, IscS, NIFS
  • Links
    NCBI Gene ID: 9054
    neXtProt AC: NX_Q9Y697
    UniProt: Q9Y697

  • Chr Location
    20q11.22; chr20:35668052-35699355 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NFS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    178
  • cDNA Data
    96
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18041 NCBI Gene Model | MGI Sequence Detail 20538 C57BL/6J ±  kb
transcript NR_185175 RefSeq | MGI Sequence Detail 2082 C57BL/6  
polypeptide Q9Z1J3 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000011184 cysteine desulfurase NFS1
    (term hierarchy)
  • EC
    2.8.1.7
  • InterPro Domains
    IPR000192 Aminotransferase class V domain
    IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site
    IPR016454 Cysteine desulfurase
    IPR010240 Cysteine desulfurase IscS
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major domain
    IPR015422 Pyridoxal phosphate-dependent transferase, small domain
  • GlyGen
    Q9Z1J3 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 96
    cDNA 96

    Microarray probesets 8
Other
Accession IDs
less
MGI:2138826
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 16
    Phenotypes 11
  • Earliest
    J:49555 Nakai Y, et al., cDNA cloning and characterization of mouse nifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins. FEBS Lett. 1998 Aug 14;433(1-2):143-8
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory