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Fga Gene Detail
Summary
  • Symbol
    Fga
  • Name
    fibrinogen alpha chain
  • Synonyms
    ENSMUSG00000059807, Fib
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316726
    NCBI Gene: 14161
  • Alliance
  • Transcription Start Sites
    43 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82933460-82940934 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 36.96 cM, cytoband F1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    313 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316726
protein coding gene Chr3:82933383-82940934 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027332
protein coding gene Chr3:82849375-82856916 (+)
A/J MGP_AJ_G0027296
protein coding gene Chr3:80119668-80127208 (+)
AKR/J MGP_AKRJ_G0027262
protein coding gene Chr3:82025319-82032883 (+)
BALB/cJ MGP_BALBcJ_G0027305
protein coding gene Chr3:80211181-80218745 (+)
C3H/HeJ MGP_C3HHeJ_G0027049
protein coding gene Chr3:82311442-82318985 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027751
protein coding gene Chr3:85967660-85975213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025104
protein coding gene Chr3:75839057-75846679 (+)
CAST/EiJ MGP_CASTEiJ_G0026496
protein coding gene Chr3:82495829-82503352 (+)
CBA/J MGP_CBAJ_G0027024
protein coding gene Chr3:88874018-88881534 (+)
DBA/2J MGP_DBA2J_G0027160
protein coding gene Chr3:79662524-79670079 (+)
FVB/NJ MGP_FVBNJ_G0027128
protein coding gene Chr3:77944238-77951789 (+)
LP/J MGP_LPJ_G0027268
protein coding gene Chr3:83836864-83844392 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027147
protein coding gene Chr3:95265091-95272639 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027809
protein coding gene Chr3:81820233-81827795 (+)
PWK/PhJ MGP_PWKPhJ_G0026230
protein coding gene Chr3:79423508-79431176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026046
protein coding gene Chr3:81011726-81019302 (+)
WSB/EiJ MGP_WSBEiJ_G0026574
protein coding gene Chr3:82155405-82162954 (+)



Homology
more
  • Human Ortholog
    FGA, fibrinogen alpha chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGA, fibrinogen alpha chain
  • Synonyms
    AMYLD2, Fib2
  • Links
    NCBI Gene ID: 2243
    neXtProt AC: NX_P02671
    UniProt: P02671

  • Chr Location
    4q31.3; chr4:154583126-154590742 (-)  GRCh38

Human Diseases
more
  • Diseases
    4 with human FGA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have blood that is unable to clot. On some genetic backgrounds this can lead to fatal hemorrhaging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14161 NCBI Gene Model | MGI Sequence Detail 7475 C57BL/6J ±  kb
    transcript NM_010196 RefSeq | MGI Sequence Detail 3370 ZRU/MplStud  
    polypeptide E9PV24 UniProt | EBI | MGI Sequence Detail 789 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007471 fibrinogen alpha chain
    • InterPro Domains
      IPR037579 Fibrinogen
      IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR021996 Fibrinogen alpha C domain
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      E9PV24 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 198
      Genomic 1
      cDNA 194
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139659, MGI:3642492
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 10
      Phenotypes 85
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:337758 Mendiola AS, et al., Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023 Jul;24(7):1173-1187

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/12/2024
    MGI 6.24
    The Jackson Laboratory