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Mpp3 Gene Detail
Summary
  • Symbol
    Mpp3
  • Name
    membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
  • Synonyms
    Dlgh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328354
    NCBI Gene: 13384
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101890478-101919287 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    978 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328354
 protein coding gene Chr11:101890478-101925854 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019217
 protein coding gene Chr11:104941701-104971188 (-)
A/J MGP_AJ_G0019185
 protein coding gene Chr11:100510322-100539088 (-)
AKR/J MGP_AKRJ_G0019154
 protein coding gene Chr11:103624689-103654672 (-)
BALB/cJ MGP_BALBcJ_G0019159
 protein coding gene Chr11:100995017-101024585 (-)
C3H/HeJ MGP_C3HHeJ_G0018968
 protein coding gene Chr11:103828941-103857516 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019608
 protein coding gene Chr11:108213246-108243355 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017234
 protein coding gene Chr11:97935051-97963736 (-)
CAST/EiJ MGP_CASTEiJ_G0018522
 protein coding gene Chr11:104794415-104824541 (-)
CBA/J MGP_CBAJ_G0018937
 protein coding gene Chr11:112680302-112711456 (-)
DBA/2J MGP_DBA2J_G0019049
 protein coding gene Chr11:100036268-100065698 (-)
FVB/NJ MGP_FVBNJ_G0019039
 protein coding gene Chr11:99562030-99592223 (-)
LP/J MGP_LPJ_G0019118
 protein coding gene Chr11:105457710-105489998 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019070
 protein coding gene Chr11:112208152-112242739 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019646
 protein coding gene Chr11:103986858-104015483 (-)
PWK/PhJ MGP_PWKPhJ_G0018285
 protein coding gene Chr11:101096309-101127289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018077
 protein coding gene Chr11:103734088-103770998 (-)
WSB/EiJ MGP_WSBEiJ_G0018571
 protein coding gene Chr11:103970038-103998563 (-)



Homology
more
  • Human Ortholog
    MPP3, MAGUK p55 scaffold protein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPP3, MAGUK p55 scaffold protein 3
  • Synonyms
    DLG3
  • Links
    NCBI Gene ID: 4356
    neXtProt AC: NX_Q13368
    UniProt: Q13368

  • Chr Location
    17q21.31; chr17:43800799-43833170 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    933
  • Tissues
    43
  • cDNA Data
    21
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052373 Ensembl Gene Model | MGI Sequence Detail 28810 C57BL/6J ±  kb
    transcript ENSMUST00000062801 Ensembl | MGI Sequence Detail 2848 Not Applicable  
    polypeptide ENSMUSP00000055469 Ensembl | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:48003 Lin L, et al., cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):211-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory