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Myom2 Gene Detail
Summary
  • Symbol
    Myom2
  • Name
    myomesin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328358
    NCBI Gene: 17930
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:15107653-15183410 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 7.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2513 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328358
 protein coding gene Chr8:15107653-15183541 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033401
 protein coding gene Chr8:12490963-12569280 (+)
A/J MGP_AJ_G0033382
 protein coding gene Chr8:12053718-12127919 (+)
AKR/J MGP_AKRJ_G0033312
 protein coding gene Chr8:12351322-12422693 (+)
BALB/cJ MGP_BALBcJ_G0033382
 protein coding gene Chr8:12126413-12201029 (+)
C3H/HeJ MGP_C3HHeJ_G0033095
 protein coding gene Chr8:12578964-12649648 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033894
 protein coding gene Chr8:12870040-12942259 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030860
 protein coding gene Chr8:11454057-11524384 (+)
CAST/EiJ MGP_CASTEiJ_G0032417
 protein coding gene Chr8:12395541-12465377 (+)
CBA/J MGP_CBAJ_G0033068
 protein coding gene Chr8:13410460-13484149 (+)
DBA/2J MGP_DBA2J_G0033222
 protein coding gene Chr8:11963320-12037925 (+)
FVB/NJ MGP_FVBNJ_G0033170
 protein coding gene Chr8:11998270-12069540 (+)
LP/J MGP_LPJ_G0033315
 protein coding gene Chr8:12469194-12557892 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033207
 protein coding gene Chr8:13627904-13706343 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033911
 protein coding gene Chr8:12439319-12515741 (+)
PWK/PhJ MGP_PWKPhJ_G0032130
 protein coding gene Chr8:12030848-12103567 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031971
 protein coding gene Chr8:12329769-12416256 (+)
WSB/EiJ MGP_WSBEiJ_G0032533
 protein coding gene Chr8:12473402-12543920 (+)



Homology
more
  • Human Ortholog
    MYOM2, myomesin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYOM2, myomesin 2
  • Synonyms
    TTNAP
  • Links
    NCBI Gene ID: 9172
    neXtProt AC: NX_P54296
    UniProt: P54296

  • Chr Location
    8p23.3; chr8:2045046-2165552 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    32
  • cDNA Data
    15
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17930 NCBI Gene Model | MGI Sequence Detail 75758 C57BL/6J ±  kb
transcript NM_001414185 RefSeq | MGI Sequence Detail 5658 C57BL/6  
polypeptide NP_001401119 RefSeq | MGI Sequence Detail 1516 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR050964 Striated Muscle Structural and Regulatory Protein
  • GlyGen
    Q14BI5 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 23
    Genomic 4
    cDNA 15
    Primer pair 4

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142771
References
more
  • Summaries
    All 40
    Developmental Gene Expression 11
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:32589 Schiaffino S, et al., Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996 Apr;76(2):371-423
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory