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Arid3a Gene Detail
Summary
  • Symbol
    Arid3a
  • Name
    AT-rich interaction domain 3A
  • Synonyms
    Bright, Dri1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328360
    NCBI Gene: 13496
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79762877-79790852 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328360
 protein coding gene Chr10:79762877-79790852 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017472
 protein coding gene Chr10:80492259-80523534 (+)
A/J MGP_AJ_G0017450
 protein coding gene Chr10:77682875-77711454 (+)
AKR/J MGP_AKRJ_G0017411
 protein coding gene Chr10:79800614-79828431 (+)
BALB/cJ MGP_BALBcJ_G0017412
 protein coding gene Chr10:77909032-77937786 (+)
C3H/HeJ MGP_C3HHeJ_G0017235
 protein coding gene Chr10:79904400-79933699 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017866
 protein coding gene Chr10:83271360-83303220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015554
 protein coding gene Chr10:73908361-73936876 (+)
CAST/EiJ MGP_CASTEiJ_G0016802
 protein coding gene Chr10:80094116-80126779 (+)
CBA/J MGP_CBAJ_G0017207
 protein coding gene Chr10:86494178-86528622 (+)
DBA/2J MGP_DBA2J_G0017313
 protein coding gene Chr10:76897766-76927407 (+)
FVB/NJ MGP_FVBNJ_G0017307
 protein coding gene Chr10:76075795-76106135 (+)
LP/J MGP_LPJ_G0017384
 protein coding gene Chr10:80969367-80999794 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017333
 protein coding gene Chr10:88465710-88496457 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017907
 protein coding gene Chr10:79788180-79815996 (+)
PWK/PhJ MGP_PWKPhJ_G0016583
 protein coding gene Chr10:76763480-76792404 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016372
 protein coding gene Chr10:78758531-78787763 (+)
WSB/EiJ MGP_WSBEiJ_G0016862
 protein coding gene Chr10:79810603-79839393 (+)



Homology
more
  • Human Ortholog
    ARID3A, AT-rich interaction domain 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARID3A, AT-rich interaction domain 3A
  • Synonyms
    BRIGHT, DRIL1, DRIL3, E2FBP1
  • Links
    NCBI Gene ID: 1820
    neXtProt AC: NX_Q99856
    UniProt: Q99856

  • Chr Location
    19p13.3; chr19:925732-975939 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E11.5 and E13.5 due to impaired erythropoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    125
  • cDNA Data
    31
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13496 NCBI Gene Model | MGI Sequence Detail 27976 C57BL/6J ±  kb
    transcript NM_007880 RefSeq | MGI Sequence Detail 5361 C57BL/6  
    polypeptide Q62431 UniProt | EBI | MGI Sequence Detail 601 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 31
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 12
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357897 Renaux E, et al., Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Front Cell Neurosci. 2024;18:1466056
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory