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Ccl17 Gene Detail
Summary
  • Symbol
    Ccl17
  • Name
    C-C motif chemokine ligand 17
  • Synonyms
    ABCD-2, Scya17, TARC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329039
    NCBI Gene: 20295
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95537081-95538664 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329039
 protein coding gene Chr8:95535996-95538666 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033969
 protein coding gene Chr8:96245314-96246896 (+)
A/J MGP_AJ_G0033952
 protein coding gene Chr8:92499392-92500974 (+)
AKR/J MGP_AKRJ_G0033878
 protein coding gene Chr8:95017617-95019199 (+)
BALB/cJ MGP_BALBcJ_G0033944
 protein coding gene Chr8:92579038-92580620 (+)
C3H/HeJ MGP_C3HHeJ_G0033654
 protein coding gene Chr8:95730534-95732116 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034465
 protein coding gene Chr8:99748076-99749658 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031406
 protein coding gene Chr8:86302645-86304212 (+)
CAST/EiJ MGP_CASTEiJ_G0032986
 protein coding gene Chr8:95332954-95334536 (+)
CBA/J MGP_CBAJ_G0033630
 protein coding gene Chr8:103040273-103041855 (+)
DBA/2J MGP_DBA2J_G0033784
 protein coding gene Chr8:91956805-91958387 (+)
FVB/NJ MGP_FVBNJ_G0033731
 protein coding gene Chr8:90924586-90926168 (+)
LP/J MGP_LPJ_G0033876
 protein coding gene Chr8:96394952-96396534 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033773
 protein coding gene Chr8:105337762-105339344 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034483
 protein coding gene Chr8:95184494-95186076 (+)
PWK/PhJ MGP_PWKPhJ_G0032688
 protein coding gene Chr8:91345088-91346670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032525
 protein coding gene Chr8:94018860-94020456 (+)
WSB/EiJ MGP_WSBEiJ_G0033098
 protein coding gene Chr8:95715344-95716926 (+)



Homology
more
  • Human Ortholog
    CCL17, C-C motif chemokine ligand 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL17, C-C motif chemokine ligand 17
  • Synonyms
    A-152E5.3, ABCD-2, SCYA17, TARC
  • Links
    NCBI Gene ID: 6361
    neXtProt AC: NX_Q92583
    UniProt: Q92583

  • Chr Location
    16q21; chr16:57396093-57416063 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased contact hypersensitivity and increased allograft survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    37
  • cDNA Data
    9
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031780 Ensembl Gene Model | MGI Sequence Detail 1584 C57BL/6J ±  kb
    transcript ENSMUST00000034232 Ensembl | MGI Sequence Detail 514 Not Applicable  
    polypeptide ENSMUSP00000034232 Ensembl | MGI Sequence Detail 103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:51316 Yoneyama H, et al., Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J Clin Invest. 1998 Dec 1;102(11):1933-41
    • Latest
      J:350739 Heine A, et al., Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination. Front Immunol. 2024;15:1338499
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory