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Zpr1 Gene Detail
Summary
  • Symbol
    Zpr1
  • Name
    ZPR1 zinc finger
  • Synonyms
    Zfp259, ZPR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330262
    NCBI Gene: 22687
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:46184362-46193941 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330262
 protein coding gene Chr9:46184362-46193941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034752
 protein coding gene Chr9:44905546-44913835 (+)
A/J MGP_AJ_G0034733
 protein coding gene Chr9:43619807-43629456 (+)
AKR/J MGP_AKRJ_G0034660
 protein coding gene Chr9:44509130-44517477 (+)
BALB/cJ MGP_BALBcJ_G0034724
 protein coding gene Chr9:43340734-43350188 (+)
C3H/HeJ MGP_C3HHeJ_G0034435
 protein coding gene Chr9:44982864-44994195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035245
 protein coding gene Chr9:46184948-46193412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032159
 protein coding gene Chr9:43149476-43158947 (+)
CAST/EiJ MGP_CASTEiJ_G0033757
 protein coding gene Chr9:44846100-44856781 (+)
CBA/J MGP_CBAJ_G0034407
 protein coding gene Chr9:47875803-47887853 (+)
DBA/2J MGP_DBA2J_G0034566
 protein coding gene Chr9:43490327-43500930 (+)
FVB/NJ MGP_FVBNJ_G0034507
 protein coding gene Chr9:42755177-42764452 (+)
LP/J MGP_LPJ_G0034647
 protein coding gene Chr9:45223458-45231914 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034551
 protein coding gene Chr9:49619188-49628647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035266
 protein coding gene Chr9:44426266-44436770 (+)
PWK/PhJ MGP_PWKPhJ_G0033462
 protein coding gene Chr9:43412347-43421925 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033298
 protein coding gene Chr9:44758042-44769377 (+)
WSB/EiJ MGP_WSBEiJ_G0033870
 protein coding gene Chr9:44475523-44485831 (+)



Homology
more
  • Human Ortholog
    ZPR1, ZPR1 zinc finger
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZPR1, ZPR1 zinc finger
  • Synonyms
    GKAF, ZNF259
  • Links
    NCBI Gene ID: 8882
    neXtProt AC: NX_O75312
    UniProt: O75312

  • Chr Location
    11q23.3; chr11:116773799-116788039 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, fail to form a normal trophectoderm and fail to expand the inner cell mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    24
  • cDNA Data
    75
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22687 NCBI Gene Model | MGI Sequence Detail 9580 C57BL/6J ±  kb
    transcript NM_011752 RefSeq | MGI Sequence Detail 2984 Not Specified  
    polypeptide Q62384 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 75

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143010
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 5
    • Earliest
      J:50499 Galcheva-Gargova Z, et al., Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science. 1996 Jun 21;272(5269):1797-802
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory