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Dyrk1a Gene Detail
Summary
  • Symbol
    Dyrk1a
  • Name
    dual-specificity tyrosine phosphorylation regulated kinase 1a
  • Synonyms
    2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Mnbh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330299
    NCBI Gene: 13548
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:94370869-94496376 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.30 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330299
 protein coding gene Chr16:94370770-94496378 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023073
 protein coding gene Chr16:95816066-95947815 (+)
A/J MGP_AJ_G0023041
 protein coding gene Chr16:91309129-91434240 (+)
AKR/J MGP_AKRJ_G0023011
 protein coding gene Chr16:94111552-94235668 (+)
BALB/cJ MGP_BALBcJ_G0023043
 protein coding gene Chr16:91847017-91972307 (+)
C3H/HeJ MGP_C3HHeJ_G0022804
 protein coding gene Chr16:94625168-94752511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023490
 protein coding gene Chr16:98874331-99012808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020992
 protein coding gene Chr16:89166533-89288454 (+)
CAST/EiJ MGP_CASTEiJ_G0022323
 protein coding gene Chr16:95379835-95511912 (+)
CBA/J MGP_CBAJ_G0022773
 protein coding gene Chr16:103142715-103268542 (+)
DBA/2J MGP_DBA2J_G0022907
 protein coding gene Chr16:91200327-91326431 (+)
FVB/NJ MGP_FVBNJ_G0022881
 protein coding gene Chr16:90361514-90486422 (+)
LP/J MGP_LPJ_G0022977
 protein coding gene Chr16:95476887-95608065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022902
 protein coding gene Chr16:107466812-107596159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023508
 protein coding gene Chr16:94634094-94763071 (+)
PWK/PhJ MGP_PWKPhJ_G0022068
 protein coding gene Chr16:91466746-91592981 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021898
 protein coding gene Chr16:94173160-94305770 (+)
WSB/EiJ MGP_WSBEiJ_G0022374
 protein coding gene Chr16:94887744-95017007 (+)



Homology
more
  • Human Ortholog
    DYRK1A, dual specificity tyrosine phosphorylation regulated kinase 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYRK1A, dual specificity tyrosine phosphorylation regulated kinase 1A
  • Synonyms
    DYRK, DYRK1, HP86, MNB, MNBH, MRD7
  • Links
    NCBI Gene ID: 1859
    neXtProt AC: NX_Q13627
    UniProt: Q13627

  • Chr Location
    21q22.13; chr21:37365573-37526358 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Dyrk1a mouse models; 3 with human DYRK1A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 7 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    142 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted deletion present a general embryonic growth delay and die during midgestation. Heterozygotes display reduced postnatal survival, postnatal growth retardation, microcephaly, behavioral and motor deficits, and altered neocortical pyramidal cell morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1003
  • Tissues
    151
  • cDNA Data
    140
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022897 Ensembl Gene Model | MGI Sequence Detail 125508 C57BL/6J ±  kb
    transcript ENSMUST00000023614 Ensembl | MGI Sequence Detail 5754 Not Applicable  
    polypeptide ENSMUSP00000023614 Ensembl | MGI Sequence Detail 763 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000006781 dual specificity tyrosine-phosphorylation-regulated kinase 1A
      (term hierarchy)
    • EC
      2.7.11.23, 2.7.12.1
    • InterPro Domains
      IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050494 Serine/threonine and dual-specificity kinase
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      Q61214 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 160
      Genomic 5
      cDNA 141
      Primer pair 10
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28072, MGD-MRK-38315, MGI:104780, MGI:109270, MGI:1196299, MGI:1277155, MGI:1923715
    References
    more
    • Summaries
      All 243
      Developmental Gene Expression 32
      Diseases 8
      Gene Ontology 22
      Phenotypes 142
    • Earliest
      J:29230 Patil N, et al., A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation [see comments]. Nat Genet. 1995 Oct;11(2):126-9
    • Latest
      J:354660 Manubens-Gil L, et al., Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A. Cereb Cortex. 2024 Jan 14;34(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory