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Trpm1 Gene Detail
Summary
  • Symbol
    Trpm1
  • Name
    transient receptor potential cation channel, subfamily M, member 1
  • Synonyms
    4732499L03Rik, LTRPC1, melastatin, Mlsn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330305
    NCBI Gene: 17364
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:63803583-63919523 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3564 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330305
 protein coding gene Chr7:63803583-63923630 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032334
 protein coding gene Chr7:65277908-65405809 (+)
A/J MGP_AJ_G0032313
 protein coding gene Chr7:64019405-64139826 (+)
AKR/J MGP_AKRJ_G0032249
 protein coding gene Chr7:65374848-65494915 (+)
BALB/cJ MGP_BALBcJ_G0032325
 protein coding gene Chr7:63760666-63880125 (+)
C3H/HeJ MGP_C3HHeJ_G0032038
 protein coding gene Chr7:66023478-66142111 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032818
 protein coding gene Chr7:68085169-68210289 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029825
 protein coding gene Chr7:66972098-67087371 (+)
CAST/EiJ MGP_CASTEiJ_G0031367
 protein coding gene Chr7:56713256-56838655 (+)
CBA/J MGP_CBAJ_G0032004
 protein coding gene Chr7:70303787-70434802 (+)
DBA/2J MGP_DBA2J_G0032160
 protein coding gene Chr7:62773035-62891436 (+)
FVB/NJ MGP_FVBNJ_G0032114
 protein coding gene Chr7:62873599-62991160 (+)
LP/J MGP_LPJ_G0032240
 protein coding gene Chr7:66504937-66638649 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032151
 protein coding gene Chr7:70579706-70708863 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032835
 protein coding gene Chr7:64656163-64777082 (+)
PWK/PhJ MGP_PWKPhJ_G0031087
 protein coding gene Chr7:55778866-55900100 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030928
 protein coding gene Chr7:51789973-51914440 (+)
WSB/EiJ MGP_WSBEiJ_G0031485
 protein coding gene Chr7:65033129-65160830 (+)



Homology
more
  • Human Ortholog
    TRPM1, transient receptor potential cation channel subfamily M member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPM1, transient receptor potential cation channel subfamily M member 1
  • Synonyms
    CSNB1C, LTRPC1, MLSN1
  • Links
    NCBI Gene ID: 4308
    neXtProt AC: NX_Q7Z4N2
    UniProt: Q7Z4N2

  • Chr Location
    15q13.3; chr15:31001065-31161160 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trpm1 mouse models; 2 with human TRPM1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 6 alleles in 8 genetic backgrounds
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    63
  • cDNA Data
    41
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030523 Ensembl Gene Model | MGI Sequence Detail 115941 C57BL/6J ±  kb
    transcript ENSMUST00000206277 Ensembl | MGI Sequence Detail 5076 Not Applicable  
    polypeptide ENSMUSP00000146226 Ensembl | MGI Sequence Detail 1628 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 4
      cDNA 42
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142011, MGI:3036274, MGI:4867500
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 15
      Diseases 4
      Gene Ontology 12
      Phenotypes 58
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:346902 Chang B, B6.Cg-Trpm1rd15/Boc. MGI Direct Data Submission. 2024;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory