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Dclk1 Gene Detail
Summary
  • Symbol
    Dclk1
  • Name
    doublecortin-like kinase 1
  • Synonyms
    1700113D08Rik, 2810480F11Rik, Click-I, CPG16, Dcamkl1, Dcl, DCLK, mKIAA0369
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330861
    NCBI Gene: 13175
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:55149785-55446489 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 26.53 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330861
 protein coding gene Chr3:55149724-55446489 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027223
 protein coding gene Chr3:53969982-54275980 (+)
A/J MGP_AJ_G0027183
 protein coding gene Chr3:52302459-52602351 (+)
AKR/J MGP_AKRJ_G0027153
 protein coding gene Chr3:53382880-53689696 (+)
BALB/cJ MGP_BALBcJ_G0027196
 protein coding gene Chr3:52152474-52448865 (+)
C3H/HeJ MGP_C3HHeJ_G0026939
 protein coding gene Chr3:53587107-53891708 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027642
 protein coding gene Chr3:56028277-56323736 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025001
 protein coding gene Chr3:48821062-49117877 (+)
CAST/EiJ MGP_CASTEiJ_G0026391
 protein coding gene Chr3:53738558-54045231 (+)
CBA/J MGP_CBAJ_G0026915
 protein coding gene Chr3:57808975-58151743 (+)
DBA/2J MGP_DBA2J_G0027049
 protein coding gene Chr3:51854377-52154647 (+)
FVB/NJ MGP_FVBNJ_G0027017
 protein coding gene Chr3:50849537-51148180 (+)
LP/J MGP_LPJ_G0027161
 protein coding gene Chr3:54683093-54996100 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027035
 protein coding gene Chr3:61921688-62240592 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027700
 protein coding gene Chr3:53293965-53600921 (+)
PWK/PhJ MGP_PWKPhJ_G0026123
 protein coding gene Chr3:51526992-51825358 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025936
 protein coding gene Chr3:53045812-53353204 (+)
WSB/EiJ MGP_WSBEiJ_G0026465
 protein coding gene Chr3:53418816-53731366 (+)



Homology
more
  • Human Ortholog
    DCLK1, doublecortin like kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCLK1, doublecortin like kinase 1
  • Synonyms
    CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
  • Links
    NCBI Gene ID: 9201
    neXtProt AC: NX_O15075
    UniProt: O15075

  • Chr Location
    13q13.3; chr13:35768652-36131939 (-)  GRCh38
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    36 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele lack the corpus callosum and hippocampal commissure and show aberrant interhemispheric axonal projections. Mice homozygous for a different null allele have normal gross brain architecture but show axonal and dendritic defects following knockdown of Dcx expression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1217
  • Tissues
    191
  • cDNA Data
    24
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027797 Ensembl Gene Model | MGI Sequence Detail 296705 C57BL/6J ±  kb
    transcript ENSMUST00000054237 Ensembl | MGI Sequence Detail 7847 Not Applicable  
    polypeptide ENSMUSP00000050034 Ensembl | MGI Sequence Detail 756 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      19 Sequences
    • EC
      2.7.11.1
    • InterPro Domains
      IPR049626 DCX/DCDC2-like
      IPR003533 Doublecortin domain
      IPR036572 Doublecortin domain superfamily
      IPR017302 Neuronal migration protein doublecortin, chordates
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      Q9JLM8 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 35
      Primer pair 11
      Other 6

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGI:1914611, MGI:1920056, MGI:2139800
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 13
      Phenotypes 39
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory